0
Thermo Scientific™ Hypersil GOLD™ C8 HPLC Column
Catalog No :
CAS Number :
Brand :
In Stock
Specifications:
| Application | HPLC |
| Storage Temperature | Ambient |
| Product Type | columns |
| Product Brand | Thermo Fisher Scientific™ |
| Product Grade | Analytical grade |
Fast, Efficient Reversed-Phase Separations for Moderately Hydrophobic Analytes
The Thermo Scientific™ Hypersil GOLD™ C8 HPLC Columns are engineered for exceptional peak shape, high efficiency, and superior sensitivity for analytes requiring a less hydrophobic stationary phase than traditional C18 columns. With reduced retention and faster elution, Hypersil GOLD C8 columns deliver high analytical throughput while maintaining excellent resolution and reproducibility—ideal for small molecules, fatty acids, and compounds that elute too slowly or strongly on C18 phases.
Built on ultrapure, fully porous silica with a proprietary bonding and endcapping process, these columns achieve outstanding peak symmetry across a wide range of chemical classes. Available in 1.9 μm, 3 μm, and 5 μm particle sizes, they support method development, LC-MS workflows, routine analysis, and high-speed separations with maximum reliability.
Key Features & Benefits
1. Reduced Hydrophobicity for Faster Elution
- C8 phase offers similar selectivity to C18 but with shorter retention times
- Ideal for moderately hydrophobic analytes and early-eluting compounds
- Enhances throughput by reducing run times without compromising resolution
2. Excellent Peak Shape & High Efficiency
- Fully endcapped, ultrapure silica guarantees minimized silanol interactions
- Delivers symmetrical, narrow peaks—critical for accurate quantitation
- Optimized for LC and LC-MS with enhanced sensitivity
3. Versatile Selectivity
- Predictable elution order similar to C18, easing method transfer
- Suitable for fatty acids that are too strongly retained on C18 columns
- Allows flexible method development with reliable peak reproducibility
4. Broad Dimensional Range
- Lengths from 10–250 mm
- Diameters from 1–4.6 mm
-
Particle sizes: 1.9, 3, and 5 μm
Supports UHPLC, analytical HPLC, and high-resolution separations.
5. Part of the Hypersil GOLD Family
- Highly reproducible column chemistry
- Twelve selectivities available for method optimization
- Robust performance in reversed phase, ion exchange, normal phase, and HILIC
Typical Applications
- Moderately hydrophobic small molecules
- Fatty acids & lipid derivatives
- Pharmaceutical method development
- LC-MS compatible workflows
- High-throughput analysis
- Environmental & food analytes that elute too strongly on C18
General Specifications
| Parameter | Value |
|---|---|
| Column Type | Reversed Phase |
| Stationary Phase | C8 (USP L7) |
| Packing Material | Ultrapure, fully porous spherical silica |
| Endcapped | Yes |
| Surface Area | 220 m²/g |
| Carbon Load | 8% |
| Max Temperature | 60°C |
| Format | Analytical Columns |
| Product Line | Hypersil GOLD |
| Particle Sizes | 1.9 µm, 3 µm, 5 µm |
| Unit Size | Each |
Organized by particle size for clarity.
1. Particle Size: 5 μm
| Catalog Number | Length (mm) | ID (mm) | Particle Size |
|---|---|---|---|
| 25205-254630 | 250 | 4.6 | 5 μm |
| 25205-254030 | 250 | 4.0 | 5 μm |
| 25205-154630 | 150 | 4.6 | 5 μm |
| 25205-152130 | 150 | 2.1 | 5 μm |
| 25205-104630 | 100 | 4.6 | 5 μm |
| 25205-102130 | 100 | 2.1 | 5 μm |
| 25205-054630 | 50 | 4.6 | 5 μm |
| 25205-052130 | 50 | 2.1 | 5 μm |
| 25205-014001 | 10 | 4.0 | 5 μm |
| 25205-013001 | 10 | 3.0 | 5 μm |
| 25205-012101 | 10 | 2.1 | 5 μm |
| 25205-011001 | 10 | 1.0 | 5 μm |
2. Particle Size: 8 μm (Semi-Preparative)
| Catalog Number | Length (mm) | ID (mm) | Particle Size |
|---|---|---|---|
| 25208-254630 | 250 | 4.6 | 8 μm |
3. Particle Size: 3 μm
| Catalog Number | Length (mm) | ID (mm) | Particle Size |
|---|---|---|---|
| 25203-154630 | 150 | 4.6 | 3 μm |
| 25203-153030 | 150 | 3.0 | 3 μm |
| 25203-152130 | 150 | 2.1 | 3 μm |
| 25203-104630 | 100 | 4.6 | 3 μm |
| 25203-103030 | 100 | 3.0 | 3 μm |
| 25203-102130 | 100 | 2.1 | 3 μm |
| 25203-101030 | 100 | 1.0 | 3 μm |
| 25203-054630 | 50 | 4.6 | 3 μm |
| 25203-053030 | 50 | 3.0 | 3 μm |
| 25203-052130 | 50 | 2.1 | 3 μm |
| 25203-014001 | 10 | 4.0 | 3 μm |
| 25203-013001 | 10 | 3.0 | 3 μm |
| 25203-012101 | 10 | 2.1 | 3 μm |
| 25203-011001 | 10 | 1.0 | 3 μm |
4. Particle Size: 1.9 μm (UHPLC)
| Catalog Number | Length (mm) | ID (mm) | Particle Size |
|---|---|---|---|
| 25202-152130 | 150 | 2.1 | 1.9 μm |
| 25202-102130 | 100 | 2.1 | 1.9 μm |
| 25202-101030 | 100 | 1.0 | 1.9 μm |
| 25202-052130 | 50 | 2.1 | 1.9 μm |
Hypersil GOLD™ C8 columns offer rapid, efficient separations for moderately hydrophobic analytes, providing faster elution and excellent peak shape. With particle sizes from 1.9 to 5 μm and a wide selection of dimensions, these columns provide unmatched flexibility for high-throughput, LC-MS, and routine HPLC workflows.
- Column Dimension: Particle Size: 5 μm; 250 x 4.0 mm Particle Size: 8 μm; 250 x 4.6 mm Particle Size: 3 μm; 50 x 3.0 mm Particle Size: 5 μm; 50 x 2.1 mm Particle Size: 5 μm; 50 x 4.6 mm Particle Size: 5 μm; 10 x 1.0 mm Particle Size: 5 μm; 10 x 2.1 mm Particle Size: 5 μm; 10 x 3.0 mm Particle Size: 5 μm; 10 x 4.0 mm Particle Size: 5 μm; 100 x 2.1 mm Particle Size: 5 μm; 100 x 4.6 mm Particle Size: 5 μm; 150 x 2.1 mm Particle Size: 5 μm; 150 x 4.6 mm Particle Size: 5 μm; 250 x 4.6 mm Particle Size: 3 μm; 50 x 2.1 mm Particle Size: 3 μm; 50 x 4.6 mm Particle Size: 3 μm; 100 x 1.0 mm Particle Size: 3 μm; 100 x 3.0 mm Particle Size: 3 μm; 100 x 4.6 mm Particle Size: 3 μm; 150 x 2.1 mm Particle Size: 3 μm; 150 x 3.0 mm Particle Size: 3 μm; 150 x 4.6 mm Particle Size: 3 μm; 10 x 2.1 mm Particle Size: 3 μm; 10 x 1.0 mm Particle Size: 3 μm; 10 x 4.0 mm Particle Size: 3 μm; 10 x 3.0 mm Particle Size: 1.9 μm; 50 x 2.1 mm Particle Size: 1.9 μm; 100 x 1.0 mm Particle Size: 1.9 μm; 100 x 2.1 mm Particle Size: 1.9 μm; 150 x 2.1 mm