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Thermo Scientific™ Dextran sulphate sodium salt, M.W. ∼ 500,000
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CAS Number :
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Specifications:
| Storage Temperature | 2-8°C | ||
| Product Type | Biochemical Reagent | Forms | Powder |
| Product Brand | Thermo Fisher Scientific™ | ||
| Product Grade | Analytical grade | Formula | (C₆H₇Na₃O₁₄S₃)n |
Polyanionic Polysaccharide for Colitis Research & Biomedical Applications
Thermo Fisher Scientific™ Dextran Sulfate Sodium (DSS) is a high-purity polyanionic derivative of dextran, produced by esterification of dextran with chlorosulfonic acid. DSS is widely used in biomedical and clinical research, particularly in inflammatory bowel disease (IBD) models and antiviral studies.
As a high molecular weight (≥500,000 Da) sodium salt, DSS is freely soluble in water and salt solutions, forming a stable, clear solution with controlled sulfation levels (17–20% sulfur content). This product is highly effective in inducing experimental colitis in animal models, making it an essential reagent for colitis research and IBD therapeutics evaluation.
Key Features & Benefits
✅ High Molecular Weight (≥500,000 Da) – Ensures reproducibility in biomedical applications
✅ Controlled Sulfation (17–20%) – Consistent biological activity with 1.9 sulfate groups per glucosyl residue
✅ Water-Soluble & Stable – Freely dissolves in aqueous solutions for easy preparation
✅ Proven Model for IBD Research – Induces chronic colitis in animal studies
✅ Versatile Biomedical Applications – Used in colitis studies, antiviral research, and macromolecular drug delivery
Applications
🔬 Inflammatory Bowel Disease (IBD) Research – Used to induce colitis in animal models (mice & rats)
🦠 Colitis-Associated Cancer Studies – Evaluates therapeutic interventions for IBD-related cancers
🧬 Antiviral Research – Studied as a potential antiviral agent
🛠️ Biopolymer & Drug Delivery Systems – Used in drug formulation & macromolecular studies
Product Specifications
| Attribute | Details |
|---|---|
| Chemical Name | Dextran Sulfate Sodium Salt |
| Synonyms | Dextran Sulfate Sodium from Dextran |
| Molecular Formula | (C₆H₇Na₃O₁₄S₃)n |
| CAS Number | 9011-18-1 |
| Molecular Weight | ≥500,000 Da |
| Sulfur Content | 17–20% |
| Sulfated Ash | 40–50% |
| Appearance | Off-white to light yellow powder |
| Solubility (10% in water) | Clear to slightly hazy, colorless to light yellow |
| pH (1% in water) | 5.0–7.5 |
| Specific Optical Rotation | +75° to +105° (20°C, 589 nm, c=6, water) |
| Specific Viscosity | 0.10–0.70 (1.0M NaCl, 25°C) |
| Loss on Drying | ≤10% |
| Storage Conditions | Refrigerator (2–8°C) |
Usage Guidelines
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Colitis Model Preparation:
- DSS is administered via drinking water to induce chronic colitis in experimental animals
- Concentration typically ranges from 2–5% (w/v) depending on the model
- Symptoms include epithelial damage, inflammation, and immune activation
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Solution Preparation:
- DSS is freely soluble in water and salt solutions
- Dissolve in distilled water to prepare a homogeneous solution
- Store prepared solutions at 2–8°C for short-term use or -20°C for long-term storage
Ordering Information
| Catalog Number | Pack Type | Quantity |
|---|---|---|
| 433240050 | Glass bottle | 5 g |
| 433240250 | Plastic bottle | 25 g |
| 433241000 | Plastic bottle | 100 g |
Regulatory & Safety Information
⚠️ For Research Use Only. Not intended for diagnostic, therapeutic, or human/animal use.
- Use in a controlled laboratory environment
- Handle with appropriate personal protective equipment (PPE)
- Refer to the Safety Data Sheet (SDS) for detailed handling and disposal guidelines
Why Choose Thermo Fisher Scientific™ Dextran Sulfate Sodium (DSS)?
🔹 Highly Purified & Well-Characterized – Ensures reproducibility in research applications
🔹 Validated in IBD & Colitis Models – Cited in numerous scientific studies
🔹 Stable & Easy to Use – Freely dissolves in water & salt solutions
🔹 Trusted by Researchers Worldwide – Backed by Thermo Fisher Scientific’s commitment to quality
For bulk orders, technical support, or additional information, contact LabMart Limited today.
- Pack Size: 100g 5g 25g