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Invitrogen™ ACE2 Polyclonal Antibody, 100 µL
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Species Reactivity: Human, Mouse, Rat
Host/Isotype: Rabbit / IgG
Storage buffer: PBS, pH 7, with 20% glycerol, 1% BSA
Contains: 0.025% ProClin 300
Specifications:
| Application | Western Blot, immunocytochemistry, Flow Cytometry, Immunohistochemistry, Immunofluorescence | ||
| Storage Temperature | 2-8°C | ||
| Product Type | antibody | Forms | Liquid |
| Product Brand | Thermo Fisher Scientific™ | ||
| Product Grade | Molecular Biology | ||
Product Specific Information
Keep as concentrated solution.
Predicted reactivity: Cat (81%), Rhesus Monkey (94%).
Positive Control: A549, HepG2.
Store the product as a concentrated solution. Centrifuge briefly before opening the vial.
Target Information
Angiotensin-converting enzyme 2 (ACE2) plays a central role in vascular, renal, and myocardial physiology. In contrast to its homolog ACE, ACE2 expression is restricted to heart, kidney, and testis. Recently. ACE2 has also been shown to be a functional receptor of the SARS coronavirus. The normal function of ACE2 is to convert the inactive vasoconstrictor angiotensin I (AngI) to Ang1-9 and the active form AngII to Ang1-7, unlike ACE, which converts AngI to AngII. While the role of these vasoactive peptides is not well understood, lack of ACE2 expression in ace2-/ace2- mice leads to severely reduced cardiac contractility, indicating its importance in regulating heart function.