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Thermo Scientific™ Memantine hydrochloride, 50mg
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CAS Number :
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Specifications:
| Application | Analysis | ||
| Storage Temperature | 2-8°C | ||
| Product Type | Laboratory Chemical | Forms | Powder |
| Product Brand | Thermo Fisher Scientific™, thermo Scientific | ||
| Product Grade | Analytical grade | Formula | C₁₂H₂₂ClN |
NMDA Receptor Antagonist for Neuroscience and Neuroprotection Research
Memantine Hydrochloride is a low-affinity, uncompetitive antagonist of NMDA-type glutamate receptors that also stimulates dopamine release, making it a widely used pharmacological tool in neuroscience, neuroprotection, and neurodegenerative disease research. Its action on the glutamatergic system has made it particularly valuable in the study of Alzheimer’s disease, Parkinson’s disease, epilepsy, and traumatic brain injury.
This research-grade compound is suitable for in vitro and in vivo applications, including pharmacological assays, ADME-Tox profiling, and CNS drug screening programs.
Key Features & Benefits
- NMDA receptor antagonist: Blocks excessive calcium influx and neuronal excitotoxicity
- Stimulates dopamine release: Facilitates neurotransmitter modulation studies
- Therapeutically relevant: Widely studied in neurodegenerative and neuroinflammatory models
- High-purity solid form: Ideal for use in biochemical, cellular, and animal-based assays
Applications
- Neuroprotection in Alzheimer's and Parkinson’s disease models
- Trauma and ischemia-related CNS injury studies
- Epilepsy and seizure disorder research
- ADME-Tox and BBB (blood-brain barrier) penetration studies
- Glutamate receptor pharmacology
- Neuronal culture media supplement
Biochemical/Physiological Actions
- Low-affinity NMDA receptor antagonist
- Inhibits overactivation of glutamate signaling
- Reduces neuronal cell death and excitotoxicity
- Promotes dopaminergic activity modulation
- Investigated in motor neuron disease and brain trauma
Specifications
| Attribute | Description |
|---|---|
| CAS Number | 41100-52-1 |
| Chemical Name | 3,5-Dimethyladamantan-1-amine hydrochloride |
| Molecular Formula | C₁₂H₂₂ClN |
| Molecular Weight | 215.77 g/mol |
| Form | Solid |
| Appearance | White to off-white |
| Purity | Meets elemental analysis specs |
| Storage Conditions | Store in cool, dry conditions |
| Usage | For Research Use Only (RUO) |
Ordering Information
| Product Description | Catalog No. | Quantity |
|---|---|---|
| Memantine Hydrochloride, Solid | J63830.MF | 50 mg |
Storage & Handling
- Store tightly sealed in a cool, dry, well-ventilated environment
- Protect from strong oxidizing agents
- Refer to Safety Data Sheet (SDS) for detailed precautions
Thermo Scientific™ Memantine Hydrochloride is a versatile research compound that enables scientists to explore glutamate-mediated neuronal signaling, excitotoxicity, and neuroprotection. With established roles in preclinical models of Alzheimer’s disease, epilepsy, and brain injury, Memantine continues to be a cornerstone molecule in central nervous system (CNS) pharmacology research