Liofilchem Ceftazidime-avibactam CZA 50 µg 5x50 Disc

The Liofilchem™ Ceftazidime-Avibactam (CZA) 50 µg Discs are antibiotic discs designed for antimicrobial susceptibility testing (AST) of bacterial isolates against the combination of ceftazidime and avibactam. These discs are commonly used in clinical microbiology laboratories to determine the efficacy of this advanced antibiotic combination against multidrug-resistant (MDR) Gram-negative bacteria, including extended-spectrum beta-lactamase (ESBL) and carbapenemase-producing organisms.

Key Features

1. Potent Antibiotic Combination:
   • Contains 50 µg of Ceftazidime-Avibactam per disc, combining a third-generation cephalosporin (ceftazidime) with a non-beta-lactam beta-lactamase inhibitor (avibactam).
2. Effective Against Resistant Pathogens:
   • Demonstrates activity against ESBL-producing Enterobacteriaceae and carbapenem-resistant Klebsiella pneumoniae (CRKP) and Pseudomonas aeruginosa.
3. Standardized for Reliability:
   • Manufactured according to CLSI and EUCAST guidelines to ensure consistent and reproducible results.
4. Convenient Packaging:
   • Supplied in 5 cartridges, each containing 50 discs, for a total of 250 discs, suitable for medium- to high-throughput laboratories.
5. Broad Applications:
   • Essential for guiding therapy in infections caused by MDR Gram-negative bacteria.

Specifications

Applications

1. Clinical Microbiology:
   • Evaluate the susceptibility of MDR Gram-negative bacteria, including:
     • ESBL-producing Escherichia coli and Klebsiella pneumoniae.
     • Carbapenem-resistant Pseudomonas aeruginosa.
2. Infection Control:
   • Monitor resistance patterns in hospital-acquired infections caused by MDR organisms.
3. Research:
   • Study the efficacy of ceftazidime-avibactam in combating antibiotic resistance.

Procedure for Use

1. Prepare a bacterial suspension equivalent to 0.5 McFarland standard.
2. Inoculate a Mueller-Hinton Agar plate evenly using a sterile swab.
3. Place the Ceftazidime-Avibactam 50 µg disc onto the agar surface using sterile forceps or an automated disc dispenser.
4. Incubate the plate at the recommended temperature (typically 35°C) for 16–20 hours.
5. Measure the zone of inhibition around the disc and interpret the results based on CLSI or EUCAST breakpoints.

Advantages

• Reliable and Accurate: Provides consistent and reproducible susceptibility testing results.
• Targeted Therapy Guidance: Essential for managing infections caused by MDR Gram-negative bacteria.
• Convenient Packaging: 5x50 disc format for efficient laboratory workflows.
• Standards Compliant: Ensures adherence to CLSI and EUCAST guidelines.

Packaging

• Quantity: 5 cartridges, each containing 50 discs (250 discs total).
• Storage Conditions: Store at 2°C to 8°C to maintain potency.

Why Choose Liofilchem Ceftazidime-Avibactam Discs?

• Trusted for susceptibility testing of resistant Gram-negative pathogens.
• Simplifies decision-making for effective antibiotic therapy.
• Manufactured to meet international standards for quality and reliability.