Liofilchem® Cefazolin KZ, Antimicrobial Susceptibility Discs, 30 µg

Liofilchem® Cefazolin Discs (30 µg) are high-quality antimicrobial susceptibility testing (AST) discs specifically designed for the Kirby-Bauer disk diffusion method on Mueller-Hinton agar. Each disc is precisely impregnated with 30 µg of Cefazolin, a first-generation cephalosporin widely used to assess the susceptibility of Gram-positive cocci and select Gram-negative bacilli. Manufactured under ISO 9001 and ISO 13485 quality standards, these discs offer accuracy, reproducibility, and compliance with CLSI and EUCAST testing guidelines.

Key Features

• Standardized antibiotic content: Each disc contains exactly 30 µg of Cefazolin for consistent performance.
• Regulatory compliance: Tested and validated according to CLSI and EUCAST interpretative standards.
• Sterile and user-friendly: Packaged in cartridges or canisters to maintain sterility and ensure ease of use.
• Extended shelf-life: Maintains antimicrobial potency under proper refrigerated storage.
• Clear labeling: Color-coded disc labels for easy antibiotic identification and workflow integration.

Applications and Use Cases

1. Clinical Microbiology

Used in routine diagnostics to:

• Determine the susceptibility of Staphylococcus aureus, Streptococcus spp., Escherichia coli, and Klebsiella pneumoniae.
• Assist physicians in selecting Cefazolin for:
  • Surgical prophylaxis
  • Skin and soft tissue infections (SSTIs)
  • Bone and joint infections
  • Uncomplicated urinary tract infections (UTIs)

2. Pharmaceutical Quality Control

• Evaluate the efficacy of Cefazolin drug formulations.
• Support release testing for cephalosporin-based products.

3. Research and Development

• Study resistance profiles of Gram-positive cocci and select Gram-negative bacilli.
• Monitor trends in beta-lactam susceptibility.
• Compare efficacy of Cefazolin with other first- and second-generation cephalosporins.

Use Instructions

1. Prepare Mueller-Hinton agar plates according to standard microbiological protocols.
2. Adjust inoculum to 0.5 McFarland standard.
3. Inoculate agar surface uniformly using a sterile swab.
4. Apply a Cefazolin disc (30 µg) with sterile forceps or a disc dispenser.
5. Incubate at 35 ± 2 °C for 16–18 hours.
6. Measure the diameter of the inhibition zone in millimeters.
7. Interpret results using the latest CLSI or EUCAST guidelines.

Storage and Shelf Life

• Storage Conditions: 2–8 °C (refrigerated)
• Shelf Life: Typically 24–36 months from manufacture when stored sealed and under appropriate conditions.

Liofilchem® Cefazolin KZ Discs (30 µg) provide a dependable solution for antimicrobial susceptibility testing in clinical, pharmaceutical, and academic laboratories. Their precise formulation, stable performance, and international compliance make them a trusted tool for identifying effective therapies against Gram-positive pathogens. These discs support rational antibiotic use and strengthen antimicrobial stewardship practices in healthcare and research settings.