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The L293 monoclonal antibody specifically binds to CD28 which is also known as Tp44 or T44. The CD28 antigen is a 44 kDa homodimeric type I transmembrane glycoprotein which is present on most mature T cells, thymocytes, and plasma cells. CD28 is a cell-adhesion molecule (CAM) that functions as a receptor for CD80 (B7-1) and CD86 (B7-2) antigens, which are present on activated B lymphocytes, monocytes, and dendritic cells. Interaction of the CD28 antigen with CD80 or CD86 antigens, or both, co-stimulates CD2 and CD3 antigen/T-cell antigen receptor (TCR)-dependent T-cell-mediated proliferation and cytotoxicity. The L293 antibody has been demonstrated to bind to the same molecule as clone CD28.2, another CD28-specific antibody.
742530.pdf
The L293 monoclonal antibody specifically binds to CD28 which is also known as Tp44 or T44. The CD28 antigen is a 44 kDa homodimeric type I transmembrane glycoprotein which is present on most mature T cells, thymocytes, and plasma cells. CD28 is a cell-adhesion molecule (CAM) that functions as a receptor for CD80 (B7-1) and CD86 (B7-2) antigens, which are present on activated B lymphocytes, monocytes, and dendritic cells. Interaction of the CD28 antigen with CD80 or CD86 antigens, or both, co-stimulates CD2 and CD3 antigen/T-cell antigen receptor (TCR)-dependent T-cell-mediated proliferation and cytotoxicity. The L293 antibody has been demonstrated to bind to the same molecule as clone CD28.2, another CD28-specific antibody.