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The Thermo Scientific™ Vanquish™ LightPipe™ Flow Cell (6083.0100B) is a precision-engineered optical flow cell designed exclusively for the Vanquish™ Diode Array Detector HL (DAD HL). Featuring Thermo Scientific’s advanced LightPipe™ technology, this flow cell delivers unmatched signal-to-noise performance, exceptional baseline stability, and superior detection sensitivity across UHPLC applications.
The LightPipe™ design maximizes optical efficiency through an extended light path length, ultra-low baseline noise, and minimized peak dispersion—resulting in highly accurate quantitation and reliable impurity profiling, even at trace levels. Reduced refractive index and thermal effects ensure stable, drift-free baselines, enabling robust method performance during long sequences, fast gradients, and UHPLC workflows.
Key Features & Benefits
1. Exceptional Signal-to-Noise Performance
- Long optical light path for increased sensitivity
- Ultra-low noise floor ensures reliable trace analysis
- Ideal for detecting impurities, low-level analytes, and narrow UHPLC peaks
2. Low Dispersion for High-Resolution UHPLC
- 2 μL illuminated volume
- 0.8 μL dispersion volume
- Minimizes band broadening for sharp, symmetrical UHPLC peaks
- Optimized for fast-gradient and high-efficiency separations
3. Stable Baseline for Accurate Peak Integration
- Reduced refractive index (RI) effects
- Minimized thermal influence across temperature changes
- Produces flat, drift-free chromatographic baselines
4. Robust Pressure Handling
- Maximum pressure rating: 6 MPa (60 bar / 870 psi)
- Compatible with UHPLC flow rates and long sequences
- Supports rugged routine and advanced analytical workflows
5. Designed for the DAD HL Detector
- Fully integrated with Vanquish™ Diode Array Detector HL
- Ensures maximum spectral accuracy across the full DAD HL wavelength range (190–680 nm)
- High optical throughput for superior sensitivity
Applications
- UHPLC impurity profiling
- Trace-level detection of pharmaceuticals & metabolites
- Environmental contaminant screening
- Food & beverage analysis
- Spectral peak purity determination
- Fast UHPLC separations
Specifications
| Parameter | Details |
|---|---|
| Catalog Number | 6083.0100B |
| Description | LightPipe Flow Cell, 10 mm |
| Type | Standard |
| Illuminated Volume | 2 μL |
| Dispersion Volume | 0.8 μL |
| Flow Cell Pressure Limit | 6 MPa (60 bar, 870 psi) |
| For Use With | Vanquish™ Diode Array Detector HL |
| Unit Size | Each |
The Thermo Scientific™ Vanquish™ LightPipe™ Flow Cell (10 mm) is a low-dispersion, ultra-sensitive flow cell designed for the Vanquish DAD HL, providing unmatched signal-to-noise performance, minimal baseline drift, and superior detection accuracy for UHPLC applications.
Application Brief: Fast Nevirapine Impurity Profiling Using UHPLC-DAD
The Thermo Scientific™ Vanquish™ LightPipe™ Flow Cell (6083.0100B) is a precision-engineered optical flow cell designed exclusively for the Vanquish™ Diode Array Detector HL (DAD HL). Featuring Thermo Scientific’s advanced LightPipe™ technology, this flow cell delivers unmatched signal-to-noise performance, exceptional baseline stability, and superior detection sensitivity across UHPLC applications.
The LightPipe™ design maximizes optical efficiency through an extended light path length, ultra-low baseline noise, and minimized peak dispersion—resulting in highly accurate quantitation and reliable impurity profiling, even at trace levels. Reduced refractive index and thermal effects ensure stable, drift-free baselines, enabling robust method performance during long sequences, fast gradients, and UHPLC workflows.
Key Features & Benefits
1. Exceptional Signal-to-Noise Performance
- Long optical light path for increased sensitivity
- Ultra-low noise floor ensures reliable trace analysis
- Ideal for detecting impurities, low-level analytes, and narrow UHPLC peaks
2. Low Dispersion for High-Resolution UHPLC
- 2 μL illuminated volume
- 0.8 μL dispersion volume
- Minimizes band broadening for sharp, symmetrical UHPLC peaks
- Optimized for fast-gradient and high-efficiency separations
3. Stable Baseline for Accurate Peak Integration
- Reduced refractive index (RI) effects
- Minimized thermal influence across temperature changes
- Produces flat, drift-free chromatographic baselines
4. Robust Pressure Handling
- Maximum pressure rating: 6 MPa (60 bar / 870 psi)
- Compatible with UHPLC flow rates and long sequences
- Supports rugged routine and advanced analytical workflows
5. Designed for the DAD HL Detector
- Fully integrated with Vanquish™ Diode Array Detector HL
- Ensures maximum spectral accuracy across the full DAD HL wavelength range (190–680 nm)
- High optical throughput for superior sensitivity
Applications
- UHPLC impurity profiling
- Trace-level detection of pharmaceuticals & metabolites
- Environmental contaminant screening
- Food & beverage analysis
- Spectral peak purity determination
- Fast UHPLC separations
Specifications
| Parameter | Details |
|---|---|
| Catalog Number | 6083.0100B |
| Description | LightPipe Flow Cell, 10 mm |
| Type | Standard |
| Illuminated Volume | 2 μL |
| Dispersion Volume | 0.8 μL |
| Flow Cell Pressure Limit | 6 MPa (60 bar, 870 psi) |
| For Use With | Vanquish™ Diode Array Detector HL |
| Unit Size | Each |
The Thermo Scientific™ Vanquish™ LightPipe™ Flow Cell (10 mm) is a low-dispersion, ultra-sensitive flow cell designed for the Vanquish DAD HL, providing unmatched signal-to-noise performance, minimal baseline drift, and superior detection accuracy for UHPLC applications.
![[VH-D10-A] Thermo Scientific™ Vanquish™ Diode Array Detector (DAD) HL](/web/image/product.product/20260/image_512/%5BVH-D10-A%5D%20Thermo%20Scientific%E2%84%A2%20Vanquish%E2%84%A2%20Diode%20Array%20Detector%20%28DAD%29%20HL?unique=96c5da2)