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Thermo Scientific™ Octyl-beta-Glucoside ≥ 99%
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Specifications:
| Application | Protein Biology, Protein crystallography | ||
| Storage Temperature | 2-8°C | ||
| Product Type | Molecular Biology Reagent | Forms | Powder |
| Product Brand | Thermo Fisher Scientific™, thermo Scientific | ||
| Product Grade | Molecular Biology | Formula | C₁₄H₂₈O₆ |
Non-Ionic, Biocompatible Detergent for Membrane Protein Solubilization and Structural Biology Applications
Thermo Scientific™ Octyl-β-D-glucoside (OG) is a high-purity, non-ionic detergent widely used in biochemical, biophysical, and structural biology research for the solubilization and stabilization of membrane proteins. Derived from glucose and containing an octyl alkyl chain, OG is particularly valued for its mild, non-denaturing properties, allowing researchers to maintain the native conformation and functionality of proteins during extraction, purification, and crystallization workflows.
Its low UV absorbance and defined micelle-forming properties make OG highly suitable for spectroscopic, chromatographic, and crystallographic applications.
Key Features & Benefits
- Non-Ionic & Gentle – Minimizes protein denaturation; suitable for delicate membrane proteins
- High Aqueous Solubility – Forms clear and stable solutions, even at high concentrations
- Defined Micelle Behavior – Facilitates consistent protein solubilization with predictable behavior
- Low UV Absorbance – Ideal for absorbance-based detection or spectroscopic analysis
- High Purity for Research Use – ≥99% purity, suitable for sensitive and high-resolution workflows
Applications
- Membrane Protein Extraction – Solubilizes integral membrane proteins for biochemical and structural analysis
- Protein Crystallization – Commonly used in X-ray crystallography and NMR sample preparation
- Structural Biology – Suitable for cryo-EM, SAXS, and other protein conformation studies
- Liposome & Micelle Studies – Model membrane systems, protein-lipid interaction analysis
- Protein Refolding – Supports reconstitution of functional proteins from denatured states
Technical Specifications
| Attribute | Specification |
|---|---|
| Product Name | Octyl-β-D-glucoside (OG) |
| Catalog Number | 28310 |
| Molecular Formula | C14H28O6 |
| Molecular Weight | 292.37 g/mol |
| Purity | ≥99% (by HPLC) |
| CMC | 23–25 mM (0.6716–0.73% w/v) |
| Aggregation Number | ~27 |
| Micelle Molecular Weight | ~8000 g/mol |
| Cloud Point | >100°C |
| UV Absorbance (280 nm) | <0.01 AU (1% solution) |
| Form | Lyophilized powder |
| Solubility | Highly soluble in water |
| Unit Size | 5 g |
| Storage Conditions | Store within 2-8°C |
| Regulatory Use | For Research Use Only; not for diagnostic use |
Storage & Handling
- Store tightly capped in a freezer (2-8°C)
- Avoid moisture exposure; desiccator recommended after opening
- Use gloves and eye protection when handling dry powder or concentrated solutions
- Reconstitute in ultrapure water or buffer immediately before use
Thermo Scientific™ Octyl-β-D-glucoside (OG) is a trusted, high-purity detergent solution for researchers conducting membrane protein studies, protein crystallization, and structural biology. Its gentle non-ionic properties, excellent solubility, and reliable micelle formation make it a cornerstone reagent in advanced biochemical and proteomics workflows.