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Thermo Scientific™ Vanquish™ Diode Array Detector (DAD) HL
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Wavelength range: 190 to 680 nm
Specifications:
| Application | HPLC | Warranty | 1 Year |
| Storage Temperature | Ambient | ||
| Product Type | Analytical Instrument | ||
| Product Brand | Thermo Fisher Scientific™ | ||
| Product Grade | Analytical grade | ||
The Thermo Scientific™ Vanquish™ Diode Array Detector HL (DAD HL) is a premium, high-sensitivity UV-Vis detector engineered to deliver superior spectral performance, outstanding linearity, and exceptional stability for HPLC and UHPLC workflows. Designed for integration into the Vanquish Flex and Vanquish Horizon UHPLC systems, the DAD HL combines advanced optical engineering with state-of-the-art electronics to provide industry-leading detection capabilities across a wide range of analytical applications, including pharmaceutical QC, biopharmaceutical research, environmental testing, food analysis, and academic research.
With a wavelength range of 190–680 nm, advanced LightPipe™ technology, fast acquisition rates, and extremely low noise levels, the Vanquish™ DAD HL provides the precision and reliability required for demanding UHPLC separations, peak purity assessments, and spectral analysis of trace impurities.
Key Performance Features
1. Exceptional Signal-to-Noise & Sensitivity
The detector incorporates LightPipe™ technology, a proprietary long-path optical flow cell design optimized for:
- Extremely low baseline noise (< ±3 µAU at 230 nm)
- High light throughput and minimal dispersion
- Increased optical path length for superior sensitivity
- Accurate detection of trace-level impurities alongside major peaks
This results in highly stable baselines and excellent detection limits, even in ultrafast UHPLC methods.
2. Ultra-Wide Dynamic Range
- Linearity up to 2.7 AU enables measurement of both highly concentrated main components and low-level impurities in a single run.
- Supports quantitation across broad concentration ranges without requiring dilution or multiple injections.
3. High-Speed Spectral Acquisition
Designed for ultrafast chromatography and MS-compatible workflows:
- Up to 250 Hz data acquisition rate
- 10 simultaneous absorption channels + 3D spectral field
- Excellent peak shape fidelity in narrow UHPLC peaks
- Real-time spectral data for peak purity and identification
4. Advanced Optical & Thermal Stability
- Reduced refractive index effects
- Minimal thermal drift (< 0.5 mAU/hour)
- Stable detection under fluctuating laboratory temperatures
- Enhanced reliability for long sequences and QC batches
5. Smart, GLP-Compliant Operation
The detector includes multiple automated monitoring and compliance features:
- Lamp usage tracking (age, ignitions, degradation)
- Leak detection
- Self-diagnostics at power-up (optics, fans, electronics)
- Chromeleon CDS audit trail integration
- Internal wavelength validation using a holmium oxide filter
These features support regulated environments and ensure consistent method performance.
Technology & Flow Cell Options
LightPipe™ Flow Cells
-
Standard LightPipe Flow Cell (10 mm)
Ideal for most UHPLC/HPLC applications; balances dispersion and sensitivity. -
High-Sensitivity LightPipe Flow Cell (60 mm)
Designed for trace-level analysis and low-concentration samples. -
LightPipe Diagnostic Cell
For troubleshooting and performance validation.
All flow cells support pressures up to 6 MPa (60 bar).
Applications
- Pharmaceutical API/impurity profiling
- Stability-indicating UHPLC methods
- Peptide, protein, and biopharmaceutical UV analysis
- Environmental contaminant detection
- Food and beverage quality testing
- Academic and industrial R&D
- Peak purity and spectral fingerprinting
- High-throughput UHPLC separations
Specifications
| Parameter | Value |
|---|---|
| Description | Vanquish Diode Array Detector HL |
| Detector Type | Single-beam, Diode Array Detector |
| Wavelength Range | 190–680 nm |
| Wavelength Accuracy | ±1 nm |
| Wavelength Repeatability | ±0.1 nm |
| Spectral Bandwidth | Pixel: 0.5 nm; Optical resolution: 1 nm (FWHM with 1 nm slit) |
| Slit Width | 1 mm, 2 mm, 4 mm, 8 nm |
| Photodiode Array | 1024-element |
| Data Collection Rate | Up to 200–250 Hz |
| Flow Cell Volume | 10 mm (standard), 60 mm (high sensitivity), diagnostic |
| Noise | < ±3 μAU (230 nm, std cell, BW 4 nm, slit 4 nm, TC 2 s) |
| Drift | < 0.5 mAU/hour at 230 nm |
| Max Operating Pressure | 6 MPa (60 bar) |
| Number of Channels | 10 + 3D spectral field |
| Electrical Requirements | 100–240 VAC, 50/60 Hz, max. 150 W |
| Connectivity | USB 2.0 + 3-port HUB for additional modules |
| Temperature Range | 5–35 °C; 20–80% RH (non-condensing) |
| GLP Features | Lamp tracking, leak detection, service monitoring |
| Lamp | Deuterium lamp |
| Weight | 17 kg |
| Dimensions (L × W × H) | 160 × 420 × 620 mm |
The Thermo Scientific™ Vanquish™ Diode Array Detector HL delivers exceptional UV-Vis performance for UHPLC workflows, featuring LightPipe™ technology, ultra-low noise, high-speed spectral acquisition, and broad dynamic range. Ideal for pharmaceutical, environmental, and research laboratories requiring sensitive, reliable, and compliant UV detection.