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Thermo Scientific™ Vanquish™ Column Compartment H
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Specifications:
| Application | HPLC | Warranty | 1 Year |
| Storage Temperature | Ambient | ||
| Product Type | Analytical Instrument | ||
| Product Brand | Thermo Fisher Scientific™ | ||
| Product Grade | Analytical grade | ||
The Thermo Scientific™ Vanquish™ Column Compartment H is an advanced, high-performance column thermostatting module designed to deliver precise and consistent thermal control for UHPLC separations. Compatible with the Vanquish Flex UHPLC and Vanquish Horizon UHPLC systems, this column compartment ensures optimal chromatographic reproducibility, excellent peak shapes, and efficient method transfer—especially under demanding UHPLC conditions.
The compartment integrates both active and passive eluent pre-heating, two column thermostatting modes, and outstanding temperature stability to ensure the eluent entering the column matches the column’s thermal environment. This minimizes thermal mismatch, enhances efficiency, and ensures the best possible separation reliability.
Key Features & Benefits
1. Wide Temperature Range for Flexible Method Development
- Temperature control from 5 °C (up to 18 K below ambient) to 120 °C
- Enables robust UHPLC method development across a broad range of analytes
- Supports temperature-sensitive separations, stability studies, and specific retention needs
2. Dual Thermostatting Modes
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Still-air thermostatting
- Minimizes thermal mismatch
- Optimizes separation efficiency under high-pressure UHPLC conditions
- Ideal for consistent peak shapes and maximum resolution
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Forced-air thermostatting
- Accelerates thermal equilibration
- Provides flexibility for transferring methods from other HPLC/UHPLC platforms
- Suitable for high-throughput environments with frequent method changes
3. Advanced Thermal Control
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Active eluent pre-heating
- Ensures the mobile phase reaches the target temperature before entering the column
- Reduces band broadening from temperature gradients
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Post-column cooling (exclusive to Column Compartment H)
- Protects thermally sensitive detectors, including MS and refractive index detectors
- Ensures consistent detection conditions for temperature-dependent analytes
4. Multi-Column Capability
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Accommodates:
- 2 × 300 mm columns with pre-heater or guard column (ID ≤ 10 mm)
- 2 × 250 mm columns with pre-heater and guard column
- Supports a wide range of column dimensions for routine and advanced workflows
5. Ready for Advanced LC Workflows
Supports installation of up to two optional switching valves, enabling:
- Tandem LC
- LC–MS workflows
- Online SPE
- Trap-and-loop heart-cut 2D-LC
- Additional sample preparation and fractionation techniques
This significantly expands the analytical capabilities of the Vanquish system while maintaining excellent thermal control.
Applications
- UHPLC method development and optimization
- High-resolution separations
- Pharmaceutical QC and R&D
- Environmental and food analysis
- LC–MS workflows requiring precise temperature consistency
- Multi-column workflows (SPE, 2D-LC, online cleanup)
- Temperature-sensitive separations
Specifications
| Parameter | Details |
|---|---|
| Catalog Number | VH-C10-A-03 |
| Description | Vanquish Column Compartment H |
| For Use With | Vanquish Flex UHPLC System, Vanquish Horizon UHPLC System |
| Temperature Range | 5 °C (max. 18 K below ambient) to 120 °C |
| Column Capacity | 2 × 300 mm (with pre-heater or guard); 2 × 250 mm (with pre-heater & guard) |
| Maximum Column ID | 10 mm |
| Type | Column Compartment |
| Unit Size | Each |
The Thermo Scientific™ Vanquish™ Column Compartment H delivers precise and flexible temperature control for UHPLC workflows, offering dual thermostatting modes, advanced eluent pre-heating, post-column cooling, and support for multi-column advanced workflows. Optimized for Vanquish Flex and Horizon systems, it ensures reliable, high-resolution separations and consistent chromatographic performance.