Thermo Scientific™ Dowex® 50WX2 (H) 200-400 mesh

Dowex® 50WX2 is a strongly acidic cation-exchange resin in its H+ form. This resin is composed of a polystyrene matrix cross-linked with 2% divinylbenzene and contains sulphonic acid functional groups as the primary active sites. It is widely used in laboratory and industrial applications for ion exchange, catalysis, and sample preparation.

Key Features:

1. Matrix: Polystyrene cross-linked with 2% divinylbenzene.
2. Functional Group: Sulphonic acid, enabling efficient ion exchange.
3. Particle Size:
   • <50 µm: ≤15.0%

   • 210 µm: ≤15.0%

4. Moisture Holding Capacity: 74-82%.
5. Capacity: ≥0.6 eq/L by wetted bed volume.
6. pH Range: Operates across a wide pH range of 0–14.
7. Form: Hydrogen form (H⁺).
8. Mesh Size: 200–400 mesh.

Applications:

1. Catalysis:

• Selective Monotetrahydropyranylation of Symmetrical Diols:
  • Dowex® 50WX2 is used as a catalyst to protect one hydroxyl group in diols while leaving the other group unprotected, enabling selective reactions.
• Selective Monoesterification of Dicarboxylic Acids:
  • Facilitates the conversion of one carboxyl group in dicarboxylic acids into an ester.

2. Calcium Removal:

• From Aqueous Samples:
  • The resin efficiently removes calcium ions from water and other solutions by exchanging calcium for hydrogen ions.

3. Drug Delivery Studies:

• Used as a matrix for drug loading and controlled release applications, as demonstrated in studies.

4. Ion-Exchange Chromatography:

• Separates ions and polar molecules based on their charge properties, making it suitable for water purification, desalination, and biological sample preparation.

Chemical Properties:

• Moisture Holding Capacity: 74-82%.
• Ion Exchange Capacity: ≥0.6 eq/L (wetted bed volume).
• Functional Stability: Maintains stability in highly acidic (pH 0) and basic (pH 14) conditions.
• Solubility: Insoluble in water and other solvents.

Physical Properties:

• Appearance: Strongly acidic resin in spherical bead form.
• Mesh Size: 200–400 mesh, providing high surface area and efficient ion-exchange capacity.

Handling and Storage:

• Storage Conditions:
  • Store in a cool, dry place.
  • Keep the container tightly closed to avoid moisture absorption.
  • Avoid exposure to oxidizing agents.
• Safety Notes:
  • For Research Use Only (RUO).
  • Handle with care to avoid inhalation of fine particles.

Packaging Options:

• 50 g: Catalog No. L13945.18 (L13945-18)
• 250 g: Catalog No. L13945.30 (L13945-30)
• 1,000 g (1 kg): Catalog No. L13945.0B (L13945-0B)

Key Benefits:

1. Wide pH Range:
   • Operates efficiently across the full pH spectrum, from 0 to 14, making it versatile for acidic and basic reactions.
2. Selective Catalysis:
   • Facilitates specific reactions such as monotetrahydropyranylation and monoesterification, increasing reaction yield and purity.
3. Ion-Exchange Efficiency:
   • Excellent for water softening, desalination, and removal of metal ions like calcium.
4. Research Versatility:
   • Suitable for drug delivery matrices, chromatography, and chemical synthesis.

References:

• Drug Loading and Release Properties:
  • Seong Hoon Jeong et al., International Journal of Pharmaceutics, 2008, 361(1), 26–32.

Typical Applications in Detail:

• Water Treatment: Efficient calcium removal for softening water or preparing samples for analysis.
• Pharmaceutical Research: Preparation of drug delivery systems to study controlled release mechanisms.
• Chemical Synthesis: Key catalyst in organic reactions for precise modifications like esterification and etherification.

Dowex® 50WX2 offers researchers and industrial users a reliable and versatile tool for ion exchange and catalytic applications.