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Sigma-Aldrich™ HATU 97%, for peptide synthesis
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Specifications:
| Application | Peptide Synthesis | ||
| Storage Temperature | 2-8°C | ||
| Product Type | Amino Acid & Biochemicals | Forms | Solid |
| Product Brand | Sigma-Aldrich | ||
| Product Grade | Analytical grade | Formula | C₁₀H₁₅F₆N₆OP |
HATU is a highly efficient peptide coupling reagent used for amide bond formation in solid-phase peptide synthesis (SPPS), solution-phase peptide synthesis, pharmaceutical research, and organic synthesis. Its full chemical name is O-(7-Azabenzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium hexafluorophosphate.
HATU efficiently activates carboxyl groups, enabling rapid coupling with amines to form peptide and amide bonds. It is widely preferred for challenging peptide sequences because it offers high coupling efficiency, fast reaction kinetics, and reduced racemization compared with many conventional coupling reagents.
Key Features
| Feature | Details |
|---|---|
| High Coupling Efficiency | Supports rapid and high-yield amide bond formation |
| Low Racemization | Helps minimize epimerization during peptide coupling |
| SPPS Compatible | Suitable for manual and automated solid-phase peptide synthesis |
| Solution-Phase Compatible | Can also be used in solution-phase amide coupling reactions |
| Useful for Difficult Sequences | Suitable for sterically hindered and complex peptide substrates |
| Versatile Research Use | Ideal for peptide synthesis, organic synthesis, drug discovery, and bioconjugation |
Chemical Properties & Identifiers
| Property | Value |
|---|---|
| Product Name | HATU, 97% |
| Full Name | O-(7-Azabenzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium hexafluorophosphate |
| CAS Number | 148893-10-1 |
| Empirical Formula | C₁₀H₁₅F₆N₆OP |
| Molecular Weight | 380.23 g/mol |
| MDL Number | MFCD27957364 |
| UNSPSC Code | 12352302 |
| Form | Solid |
| Melting Point | 183–185 °C |
| Assay | ≥97.0% by HPLC |
| Storage Temperature | 2–8 °C |
| Functional Groups | Uronium, fluorophosphate |
Applications
HATU is suitable for:
- Solid-phase peptide synthesis
- Solution-phase peptide synthesis
- Amide bond formation
- Peptide coupling reactions
- Synthesis of difficult peptide sequences
- Pharmaceutical and drug discovery research
- Peptide therapeutics development
- Bioconjugation chemistry
- Organic synthesis and selective acylation
- Macrocycle and peptide-drug conjugate synthesis
Recommended Coupling Conditions
| Parameter | Typical Condition |
|---|---|
| Solvents | DMF, DCM, or NMP |
| Bases | DIPEA or NMM |
| Temperature | Room temperature, typically 20–25 °C |
| Use | Carboxyl activation followed by amine coupling |
Ordering Information
| Catalog Number | Quantity |
|---|---|
| 445460-1G | 1 g |
| 445460-5G | 5 g |
| 445460-25G | 25 g |
| 445460-100G | 100 g |
Storage & Handling
Store at 2–8 °C in a dry, tightly sealed container. Protect from moisture and prolonged air exposure. Handle in a suitable laboratory environment, preferably in a fume hood, using appropriate personal protective equipment including gloves, lab coat, and safety goggles.
Research Use Statement
For Research Use Only (RUO). Not intended for diagnostic or therapeutic use.
- Pack Size: 100g 1g 5g 25g