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Sigma-Aldrich™ Fmoc-Glu(OtBu)-OH, ≥98.0% (HPLC), for peptide synthesis
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Specifications:
| Application | Protein Biology, Peptide Synthesis | ||
| Storage Temperature | 2-8°C | ||
| Product Type | Amino Acid & Biochemicals | Forms | Powder |
| Product Brand | Sigma-Aldrich | ||
| Product Grade | HPLC Grade | Formula | C₁₈H₁₇NO₅ |
Fmoc-Glu(OtBu)-OH is a high-purity, selectively protected glutamic acid derivative used in Fmoc-based solid-phase peptide synthesis (SPPS), peptide modification, pharmaceutical research, and bioconjugation chemistry. It features an Fmoc-protected α-amino group and a tert-butyl ester-protected γ-carboxyl group, enabling controlled peptide elongation while reducing unwanted side reactions during synthesis.
This reagent is an important building block for incorporating glutamic acid residues into synthetic peptides and is suitable for applications in custom peptide synthesis, drug discovery, protein engineering, proteomics, bioorganic chemistry, and biopolymer design.
Key Features
| Feature | Details |
|---|---|
| High Purity | ≥98.0% by HPLC for reliable peptide synthesis performance |
| Fmoc Protection | Protects the α-amino group for stepwise Fmoc-SPPS workflows |
| tBu Side-Chain Protection | Protects the γ-carboxyl group of glutamic acid |
| SPPS Compatible | Suitable for controlled incorporation of glutamic acid into peptides |
| Reduced Side Reactions | Helps prevent unwanted reactions during peptide elongation |
| Versatile Research Use | Suitable for peptide synthesis, bioconjugation, protein engineering, and drug discovery |
Chemical Properties & Identifiers
| Property | Value |
|---|---|
| Product Name | Fmoc-Glu(OtBu)-OH, ≥98.0% HPLC |
| CAS Number | 71989-18-9 |
| Empirical Formula | C₂₄H₂₇NO₆ |
| Molecular Weight | 425.47 g/mol |
| Beilstein Registry Number | 3636375 |
| EC Number | 276-253-8 |
| MDL Number | MFCD00037135 |
| PubChem Substance ID | 57651045 |
| Optical Activity | [α]²⁰/D -5.0 ± 2.0°; c = 1% in acetic acid:water, 4:1 |
| Form | Powder |
| Assay | ≥98.0% by HPLC |
| Storage Temperature | 2–8 °C |
| Functional Group | Fmoc |
| Impurities | ~4% water |
| Solubility | Soluble in organic solvents; insoluble in water |
Applications
Fmoc-Glu(OtBu)-OH is suitable for:
- Fmoc-based solid-phase peptide synthesis
- Incorporation of glutamic acid residues into synthetic peptides
- Custom peptide synthesis and peptide modification
- Peptide-based pharmaceutical and drug discovery research
- Bioconjugation and biomolecule modification workflows
- Protein engineering and proteomics research
- Bioorganic chemistry and peptidomimetic synthesis
- Biopolymer engineering and functional material research
Ordering Information
| Catalog Number | Quantity |
|---|---|
| 47625-10G | 10 g |
| 47625-25G | 25 g |
| 47625-100G | 100 g |
| 47625-1KG | 1 kg |
Storage & Handling
Store at 2–8 °C in a dry, tightly sealed container. Protect from moisture, oxidizing agents, and direct sunlight. Handle in a suitable laboratory environment using appropriate personal protective equipment, including gloves, lab coat, and safety goggles.
Research Use Statement
For Research Use Only (RUO). Not intended for diagnostic or therapeutic use.
- Pack Size: 1kg 100g 10g 25g