Abcam TMPyP4 tosylate, Telomerase inhibitor, >94%, 50mg

Potent G-Quadruplex Stabilizer for Telomerase Inhibition

TMPyP4 tosylate is a cationic porphyrin known for its potent telomerase inhibition properties (IC₅₀ = 6.5 µM). This compound binds strongly to DNA G-quadruplexes, stabilizing their structure and leading to effective telomerase inhibition. It exhibits antitumor activity and is widely used in cancer research, molecular biology, and drug discovery.

Key Features & Benefits

✅ Potent Telomerase Inhibitor

• IC₅₀ = 6.5 µM for human telomerase inhibition, preventing telomere elongation in cancer cells.
• Interferes with telomerase-dependent tumor proliferation, making it valuable in anticancer research.

✅ Binds & Stabilizes DNA G-Quadruplexes

• Enhances the formation and stability of G-quadruplex structures, which are involved in genome regulation.
• Induces telomeric DNA dysfunction, affecting oncogene expression.

✅ Highly Fluorescent in Presence of Quadruplex DNA

• Fluoresces intensely upon binding to G-quadruplex DNA, enabling fluorescence-based assays.
• Useful for DNA-protein interaction studies and quadruplex-targeting drug screening.

✅ High Purity & Stability

• Purity >94% ensures reliable and reproducible experimental results.
• Stable under desiccated (hygroscopic) conditions, allowing long-term storage.

✅ Ideal for Cancer Research & Molecular Biology Studies

• Used in preclinical research for telomerase-targeted cancer therapies.
• Supports genomic stability studies, drug screening, and structural DNA research.

Technical Specifications

Use Cases & Applications

1. Cancer Research & Telomerase Inhibition Studies

Primary Use:

• Investigates the role of telomerase in cancer progression.
• Used to test telomerase-targeting anticancer drugs.

Practical Example:

A cancer research lab uses TMPyP4 to study telomerase inhibition in glioblastoma cells, identifying potential therapeutic approaches for targeting telomerase-dependent tumors.

2. DNA G-Quadruplex Structural Studies

Primary Use:

• Helps stabilize and study G-quadruplex structures in genomic DNA.
• Used in quadruplex-targeting drug discovery.

Practical Example:

A molecular biology team applies TMPyP4 in fluorescence assays to visualize quadruplex formation in oncogene promoters, providing insights into gene regulation and stability.

3. Fluorescence-Based DNA Binding Assays

Primary Use:

• Acts as a fluorescent probe for quadruplex DNA binding studies.
• Enables DNA-protein interaction research.

Practical Example:

A biotech startup screening small-molecule drugs uses TMPyP4 fluorescence assays to identify novel inhibitors that selectively bind G-quadruplexes.

4. Preclinical Development of Telomerase-Targeted Therapies

Primary Use:

• Supports the development of novel cancer therapeutics targeting telomerase.
• Evaluates G-quadruplex-stabilizing compounds in preclinical studies.

Practical Example:

A pharmaceutical company developing telomerase inhibitors incorporates TMPyP4 in cell-based screening assays, identifying promising candidates for anticancer drug development.

Why Choose TMPyP4 for Your Research?

🔬 Selective Telomerase Inhibition – Strongly binds DNA G-quadruplexes, affecting telomerase activity in cancer cells.

💡 Fluorescent Quadruplex Binding – Enables quadruplex visualization in structural DNA studies.

⚡ High Purity & Reliable Performance – Purity >94% ensures reproducible experimental results.

📈 Preclinical Drug Discovery Potential – Widely used for developing telomerase-targeted therapies.

🛡 Stable & Easy to Handle – Long shelf life under desiccated storage conditions (2–8°C, protect from light).

TMPyP4 tosylate is a potent and highly selective telomerase inhibitor widely used in cancer research, molecular biology, and genomic stability studies. Its ability to stabilize DNA G-quadruplexes and fluoresce upon binding makes it a valuable tool for telomerase inhibition, fluorescence-based assays, and drug discovery applications.