VWR® Chloroform-[D₁] (99.8% D) + 0.03% TMS for NMR spectroscopy

VWR® Chloroform-d (CDCl₃) with 0.03% Tetramethylsilane (TMS) is a high-purity deuterated solvent designed for nuclear magnetic resonance (NMR) spectroscopy, combining both a lock solvent and a built-in chemical shift reference in a single solution.

With ≥99.8% deuterium enrichment and ≥99.9% purity, this ready-to-use formulation simplifies NMR workflows by eliminating the need for separate addition of TMS, ensuring accurate chemical shift calibration and reproducible spectral analysis.

Key Features & Benefits

1. Integrated Internal Standard (TMS)

• Contains 0.03% tetramethylsilane (TMS)
• Provides a 0 ppm reference peak for chemical shift calibration
• Eliminates manual addition of reference standard

2. High Isotopic Enrichment for NMR Performance

• ≥99.8% deuterium (D) ensures:
  • Minimal proton interference
  • Stable field-frequency lock signal

3. Ultra-High Purity

• Assay: ≥99.9% (anhydrous)
• Water content: ≤0.01%
• Ensures clean, high-resolution spectra

4. Ready-to-Use Convenience

• Pre-mixed formulation reduces:
  • Preparation time
  • Risk of contamination
  • Variability between analyses

5. Broad Solvent Compatibility

• Excellent solubility for:
  • Organic compounds
  • Pharmaceuticals
  • Natural products

Applications

• Routine ¹H and ¹³C NMR spectroscopy
• Structural elucidation of organic molecules
• Pharmaceutical and chemical research
• Reaction monitoring and purity analysis
• Quantitative NMR (qNMR) with internal reference

Technical Specifications

Ordering Information

Analytical Significance

This solvent provides two essential NMR functions:

• Deuterated solvent (CDCl₃):
  • Reduces proton background signals
  • Enables instrument lock and stability
• Tetramethylsilane (TMS):
  • Serves as a universal chemical shift reference (0 ppm)
  • Ensures accurate and consistent peak assignment

This combination is ideal for routine and high-throughput NMR analysis.

Hazard Information

⚠️ Classification: Harmful, Irritant

• UN Number: 1888
• ADR Class: 6.1 (Toxic substances)

Handle with appropriate PPE and use in a fume hood.

Unique Advantages

• All-in-one NMR solution (solvent + reference standard)
• Eliminates need for external TMS addition
• Ensures accurate chemical shift calibration
• High purity and low moisture for optimal spectral clarity
• Reliable quality from Avantor

VWR® Chloroform-d (99.8% D) with 0.03% TMS is a convenient and high-performance NMR solvent, combining deuterium lock capability with built-in chemical shift referencing. It is an ideal choice for laboratories seeking efficiency, accuracy, and reproducibility in routine and advanced NMR spectroscopy workflows.