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VWR® Chloroform-d (CDCl₃, 99.8% D) for NMR Spectroscopy
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Specifications:
| Application | NMR spectroscopy | ||
| Storage Temperature | 2-8°C | ||
| Product Type | Laboratory Chemical | Forms | Liquid |
| Product Brand | VWR | ||
| Product Grade | Analytical grade | Formula | CDCl₃ |
Chloroform-d (CDCl₃) is a high-purity deuterated solvent specifically formulated for nuclear magnetic resonance (NMR) spectroscopy. With an isotopic enrichment of ≥99.8% deuterium (D) and assay ≥99.9%, it is one of the most widely used solvents for ¹H and ¹³C NMR analysis of organic compounds.
This solvent provides a low background proton signal, enabling clear spectral interpretation while also serving as a field-frequency lock solvent in NMR instruments.
Key Features & Benefits
1. High Isotopic Enrichment for NMR Accuracy
- ≥99.8% deuterium (D) content
- Minimizes proton interference in ¹H NMR spectra
- Ensures stable lock signal for spectrometer calibration
2. Ultra-High Purity
- Assay: ≥99.9% (anhydrous basis)
- Water content: ≤0.01%
- Ensures clean spectra and reproducible results
3. Ideal for Routine & Advanced NMR Applications
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Compatible with:
- ¹H NMR
- ¹³C NMR
- 2D NMR techniques (COSY, HSQC, HMBC)
4. Excellent Solvent Properties
- Dissolves a wide range of organic compounds
- Suitable for small molecules, natural products, and pharmaceuticals
5. Stable & Convenient Packaging
- Available in sealed ampoules and glass bottles
- Maintains solvent integrity and prevents contamination
Applications
- Structural elucidation of organic compounds
- Pharmaceutical and chemical research
- Natural product analysis
- Reaction monitoring and purity assessment
- Academic and industrial NMR spectroscopy
Technical Specifications
| Parameter | Specification |
|---|---|
| Product Name | Chloroform-d |
| Chemical Formula | CDCl₃ |
| CAS Number | 865-49-6 |
| Molecular Weight | 120.38 g/mol |
| Isotopic Enrichment | ≥99.8% D |
| Assay | ≥99.9% |
| Water Content | ≤0.01% |
| Boiling Point | 60.8 °C |
| Melting Point | -64.1 °C |
| Density | 1.5 g/cm³ (20 °C) |
| Technique | NMR Spectroscopy |
| Storage | Refrigerated |
Ordering Information
| Product Code | Pack Size | Packaging |
|---|---|---|
| 87153.0006 | 10 × 0.6 mL | Glass ampoules |
| 87153.0100 | 100 mL | Glass bottle |
| 87153.0500 | 500 mL | Glass bottle |
Analytical Significance
Chloroform-d is one of the most commonly used NMR solvents due to:
- Its low residual proton signal (~7.26 ppm in ¹H NMR)
- Ability to provide a stable deuterium lock signal
- Broad solubility for non-polar to moderately polar compounds
It is essential for:
- Accurate spectral acquisition
- Quantitative NMR (qNMR)
- Chemical structure determination
Hazard Information
⚠️ Classification: Harmful, Irritant
- UN Number: 1888
- ADR Class: 6.1 (Toxic substances)
Handle with appropriate PPE and use in a well-ventilated area or fume hood.
Unique Advantages
- High isotopic purity for high-resolution NMR analysis
- Low water content ensures minimal spectral interference
- Widely accepted standard solvent in research and industry
- Suitable for both routine and advanced NMR techniques
- Reliable performance from Avantor
VWR® Chloroform-d (99.8% D) is a premium deuterated solvent essential for high-quality NMR spectroscopy. Its high isotopic enrichment, purity, and excellent solvent properties make it a cornerstone reagent for laboratories engaged in chemical analysis, structural elucidation, and research applications.
- Pack Size: 100 mL 500 mL 10 × 0.6 mL