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Protamex® Protease from Bacillus sp., >1.5 AU-N/g
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Specifications:
| Application | pharmaceutical, Protein Biology | ||
| Storage Temperature | 2-8°C | ||
| Product Type | Enzymes and Substrates | Forms | Powder |
| Product Brand | Sigma-Aldrich | ||
| Product Grade | Analytical grade | ||
Broad-Range Protease for Food, Pharmaceutical, Biotechnology, and Industrial Applications
Protamex® Protease is a broad-spectrum endopeptidase preparation derived from Bacillus species. It is designed for efficient protein hydrolysis, enzymatic digestion, and industrial bioprocessing applications where reliable proteolytic activity is required.
With a proteolytic activity of >1.5 AU-N/g, Protamex® offers strong performance across a broad pH range of pH 5.0–11.0, with optimal activity at pH 8.0 and 60°C. Its stability under moderately elevated temperature conditions makes it suitable for food processing, pharmaceutical research, biotechnology workflows, leather processing, and waste treatment applications.
Key Features
- Broad-spectrum microbial protease derived from Bacillus species
- Proteolytic activity of >1.5 AU-N/g
- Effective across a wide pH range of 5.0–11.0
- Optimal activity at pH 8.0
- Optimal operating temperature of 60°C
- Maintains high residual activity at elevated temperature
- Suitable for protein hydrolysis, enzymatic digestion, and bioprocessing
- Available in 50 g and 250 g pack sizes
- Supplied as a solid powder for convenient handling and storage
Technical Specifications
| Parameter | Details |
|---|---|
| Product Name | Protamex® Protease from Bacillus sp. |
| Enzyme Type | Broad-spectrum endopeptidase |
| Source Organism | Bacillus species |
| Enzyme Activity | >1.5 AU-N/g solid |
| Form | Solid powder |
| pH Activity Range | 5.0–11.0 |
| Optimal pH | 8.0 |
| Optimal Temperature | 60°C |
| Thermal Stability | Up to 95% residual activity at 60°C |
| Solubility | Soluble in aqueous buffers |
| Storage | Store in a cool, dry place; reseal after use |
| Intended Use | Research and industrial processing use |
Ordering Information
| Product Code | Pack Size |
|---|---|
| P0029-50G | 50 g |
| P0029-250G | 250 g |
Applications
| Application Area | Typical Use |
|---|---|
| Food and Beverage Processing | Production of protein hydrolysates, digestible peptides, and bioactive protein fractions |
| Pharmaceutical Research | Controlled protein digestion and protease inhibition studies |
| Biotechnology | Enzymatic protein processing and bioconversion workflows |
| Industrial Bioprocessing | Protein breakdown and process optimization in production systems |
| Waste Treatment | Enhancement of organic matter breakdown in industrial effluent |
| Leather Processing | Enzymatic pre-treatment and processing of hides |
| Biosensor Research | Protease biomarker detection and enzyme-based assay development |
Functional Benefits
Protamex® Protease supports efficient protein digestion across a wide range of processing conditions. Its broad pH tolerance allows use in different formulation and process environments, while its activity at elevated temperatures helps improve hydrolysis efficiency and processing yield.
The enzyme is particularly useful where consistent proteolytic performance is needed for research, development, and scale-up applications.
Storage and Handling Notes
Protamex® Protease should be stored in a cool, dry place and the container should be tightly resealed after use to protect the enzyme from moisture exposure and loss of activity.
Recommended handling considerations include:
- Avoid prolonged exposure to moisture
- Use clean, dry tools when dispensing
- Prepare working solutions using suitable aqueous buffers
- Store away from excessive heat and direct sunlight
- Follow good laboratory and industrial hygiene practices during handling
Protamex® Protease from Bacillus sp. is a versatile broad-range protease suitable for food, pharmaceutical, biotechnology, leather, waste treatment, and industrial processing applications. With high enzymatic activity, broad pH compatibility, and effective performance at elevated temperatures, it provides a reliable solution for protein hydrolysis, enzymatic digestion, and bioprocessing workflows.
- Pack Size: 250g 50g