0
Proteintech™ MUC1/CA15-3 Monoclonal Antibody (1D5D11), 150 µL
Catalog No :
CAS Number :
Brand :
In Stock
Specifications:
| Application | ELISA-Based Assays, Immunohistochemistry | ||
| Storage Temperature | -20°C | ||
| Product Type | Primary Antibodies | Forms | Liquid |
| Product Brand | Proteintech | ||
| Product Grade | Molecular Biology | ||
The Proteintech MUC1/CA15-3 Monoclonal Antibody (Clone 1D5D11) is a highly specific antibody developed for the detection of MUC1 (Mucin 1), also known as CA15-3, a widely studied epithelial glycoprotein and clinically relevant tumor-associated antigen. This antibody recognizes MUC1 derived from a fusion protein immunogen and is optimized for immunohistochemistry on paraffin-embedded tissues (IHC-P) and ELISA-based applications.
MUC1 is highly expressed in glandular epithelial tissues and is overexpressed and aberrantly glycosylated in a wide range of cancers, particularly breast carcinoma, making it an important biomarker for cancer research and tumor characterization.
Key Features
- Specific for MUC1 / CA15-3 tumor-associated antigen
- Monoclonal antibody clone 1D5D11
- Reactivity: Human
-
Validated for:
- Immunohistochemistry (Paraffin) [IHC (P)]: 1:1,600–1:6,400
- ELISA: assay-dependent
- High sensitivity for epithelial tumor detection
- Supplied as unconjugated liquid antibody
- Purified by affinity chromatography
- Stable formulation in PBS with 50% glycerol
Applications
This antibody is ideal for:
- Immunohistochemical analysis of tumor tissues
- Detection of MUC1 expression in epithelial cancers
- Breast cancer biomarker studies (CA15-3)
- ELISA-based detection of circulating tumor markers
-
Research on:
- Tumor progression and metastasis
- Glycoprotein expression and glycosylation patterns
- Cell surface antigen profiling
- Cancer diagnostics research (RUO)
Technical Specifications
| Parameter | Specification |
|---|---|
| Product Name | Proteintech MUC1/CA15-3 Monoclonal Antibody (1D5D11) |
| Catalog Number | 60749-1-Ig |
| Type | Antibody |
| Class | Monoclonal |
| Clone | 1D5D11 |
| Host / Isotype | Mouse / IgG1 |
| Species Reactivity | Human |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1000 µg/mL |
| Amount | 150 µg |
| Volume | 150 µL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Preservative | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
Immunogen Information
| Parameter | Details |
|---|---|
| Immunogen | MUC1/CA15-3 fusion protein Ag17660 |
Target Information
MUC1 (Mucin 1) is a high molecular weight transmembrane glycoprotein expressed on the surface of most glandular epithelial cells, including those of the breast, lung, and gastrointestinal tract. It contains a heavily glycosylated extracellular domain with tandem repeats, contributing to its protective and signaling functions.
In cancer, MUC1 is frequently overexpressed, aberrantly glycosylated, and mislocalized, which alters cell adhesion, signaling, and immune recognition. It is highly expressed in over 90% of breast carcinomas and is commonly used as the CA15-3 tumor marker in cancer research.
MUC1 has also been shown to interact with signaling pathways such as EGFR (ErbB1) and other ErbB family receptors, contributing to tumor progression and metastasis.
Advantages
- High specificity for epithelial tumor marker MUC1/CA15-3
- Strong performance in IHC (paraffin) applications
- Ideal for breast cancer and epithelial tumor studies
- Reliable monoclonal antibody consistency
- Suitable for both tissue-based and ELISA assays
The Proteintech MUC1/CA15-3 Monoclonal Antibody (1D5D11) is a robust and reliable reagent for investigating epithelial cancers, tumor biomarkers, and glycoprotein expression. Its validated performance in IHC and ELISA makes it a valuable tool for cancer research laboratories focusing on tumor progression, diagnostics research, and biomarker discovery.