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Invitrogen™ MUC2 Monoclonal Antibody (996/1), 500 µL
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Specifications:
| Application | Western Blot, immunocytochemistry, Flow Cytometry, Immunohistochemistry, Immunoprecipitation (IP) | ||
| Storage Temperature | 2-8°C | ||
| Product Type | Primary Antibodies | Forms | Liquid |
| Product Brand | Thermo Fisher Scientific™, Invitrogen | ||
| Product Grade | Molecular Biology | ||
The Invitrogen™ MUC2 Monoclonal Antibody (Clone 996/1) is a highly specific antibody developed for the detection of MUC2 (Mucin 2), a major secreted mucin of the intestinal epithelium. This antibody recognizes a tandem repeat peptide of MUC2, enabling accurate detection of mucin expression in both normal and diseased tissues.
MUC2 plays a critical role in forming the protective mucus barrier in the gastrointestinal tract, and its altered expression is associated with intestinal disorders, colorectal cancer, and mucinous tumors. This antibody is validated for immunohistochemistry (paraffin), immunocytochemistry, and flow cytometry, making it a versatile tool for epithelial biology and cancer research.
Key Features
- Specific for MUC2 intestinal mucin glycoprotein
- Monoclonal antibody clone 996/1
- Reactivity: Human and Mouse
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Validated for:
- Immunohistochemistry (Paraffin) [IHC (P)]: 10 µg/mL
- Flow Cytometry: 0.5–1 µg/test
- Immunocytochemistry (ICC/IF)
- Targets MUC2 tandem repeat peptide region
- Supplied as unconjugated liquid antibody
- Purified using Protein G
- Contains 0.2% BSA for protein stabilization
Applications
This antibody is ideal for:
- Immunohistochemical staining of intestinal tissues
- Detection of MUC2 expression in colorectal cancer
- Flow cytometry analysis of mucin-producing cells
- Immunocytochemistry and fluorescence imaging
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Research in:
- Gastrointestinal biology
- Mucosal barrier function
- Mucin biology and glycosylation
- Colorectal and mucinous tumor studies
Technical Specifications
| Parameter | Specification |
|---|---|
| Product Name | Invitrogen™ MUC2 Monoclonal Antibody (996/1) |
| Catalog Number | MA5-12345 |
| Type | Antibody |
| Class | Monoclonal |
| Clone | 996/1 |
| Host / Isotype | Mouse / IgG1 |
| Species Reactivity | Human, Mouse |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Amount | 50 µg |
| Volume | 500 µL |
| Purification | Protein G |
| Storage Buffer | PBS, pH 7.4, with 0.2% BSA |
| Preservative | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10975230 |
Target Information
MUC2 (Mucin 2) is the principal secreted mucin in the intestinal mucus layer, forming a critical barrier that protects epithelial cells from pathogens, toxins, and mechanical damage. It is a large, heavily O-glycosylated protein with tandem repeat regions that contribute to its gel-forming properties.
Alterations in MUC2 expression and glycosylation are associated with colorectal cancer, inflammatory bowel disease (IBD), and mucinous carcinomas. MUC2 is therefore an important biomarker for studying intestinal health, epithelial differentiation, and tumor progression.
Advantages
- High specificity for intestinal mucin MUC2
- Validated across IHC, ICC, and flow cytometry applications
- Suitable for both normal and cancer tissue analysis
- Reliable monoclonal performance for reproducible results
- Ideal for gastrointestinal and oncology research
Ordering Information
| Catalog Number | Product | Volume |
|---|---|---|
| MA5-12345 | Invitrogen™ MUC2 Monoclonal Antibody (996/1) | 500 µL |
The Invitrogen™ MUC2 Monoclonal Antibody (996/1) is a robust and versatile reagent for studying intestinal mucins, epithelial biology, and colorectal cancer. Its strong validation in tissue-based and cell-based assays makes it an essential tool for laboratories focused on gastrointestinal research and mucin-related pathologies.