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Thermo Scientific™ Kaempferol, 97%, 100 mg
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Specifications:
| Application | cell Signalling, Apoptosis | ||
| Storage Temperature | 2-8°C | ||
| Product Type | Biochemical Reagent | Forms | Solid |
| Product Brand | Thermo Fisher Scientific™, thermo Scientific | ||
| Product Grade | Molecular Biology | Formula | C₁₅H₁₀O₆ |
Thermo Scientific™ Kaempferol (≥97%) is a naturally occurring plant flavonoid with potent antioxidant, anti-inflammatory, and antitumor activities.
This compound functions as an inhibitor of fatty acid synthase (FAS), cyclooxygenase-1 (COX-1), and topoisomerase I (Topo I), while also inducing caspase-9–mediated apoptosis in cancer cells through downregulation of polo-like kinase 1 (PLK1).
Kaempferol has demonstrated ability to attenuate oxidative stress, block EGF-induced histone H3 phosphorylation, and suppress osteoclastic bone resorption, making it valuable for studies in oncology, enzymology, and cell signaling research.
Key Features
- High Purity: >97.0% (HPLC); structure confirmed by ¹H-NMR.
- Potent Enzyme Inhibitor: Inhibits FAS, COX-1, and Topoisomerase I.
- Apoptosis Inducer: Activates caspase-9 and downregulates PLK1 in multiple cancer lines.
- Antioxidant Activity: Neutralizes reactive oxygen species and reduces oxidative stress.
- Cell Signaling Modulator: Blocks EGF-induced histone H3Ser10 phosphorylation.
- Solubility: Soluble in DMSO or ethanol (up to 100 mM).
- Light Sensitive: Store in dark, dry conditions.
- Research Use Only (RUO): For laboratory applications; not for diagnostic use.
Chemical Identifiers
| Property | Value |
|---|---|
| IUPAC Name | 3,4′,5,7-tetrahydroxyflavone |
| Synonyms | Kaempferol, 3,4′,5,7-tetrahydroxyflavone |
| CAS Number | 520-18-3 |
| Molecular Formula | C₁₅H₁₀O₆ |
| Molecular Weight | 302.24 g/mol |
| InChI Key | N/A |
| SMILES | C1=CC(=C(C=C1O)O)C2=CC(=O)C3=C(O2)C=CC(=C3O)O |
Specifications
| Parameter | Specification |
|---|---|
| Purity (HPLC) | >97.0% |
| ¹H-NMR | Consistent with structure |
| Form | Solid |
| Color | Light yellow to tan powder |
| Solubility | Soluble in DMSO or ethanol to 100 mM |
| Storage Conditions | Cool, dry, and dark place |
| Stability | Light-sensitive; avoid oxidizing agents |
| Intended Use | Research Use Only (RUO) |
Applications
- Cancer Research: Investigating apoptosis and kinase downregulation in tumor cells.
- Enzyme Inhibition Studies: Inhibition of FAS, COX-1, and Topoisomerase I.
- Oxidative Stress Studies: Assessment of antioxidant and free radical–scavenging effects.
- Bone Biology: Inhibition of osteoclast-mediated bone resorption.
- Signal Transduction Research: Analysis of EGF-mediated histone phosphorylation.
- Pharmacology and Biochemistry: Flavonoid bioactivity and natural product mechanism studies.
References
- Montero, M. et al. “Direct activation of the mitochondrial calcium uniporter by plant flavonoids.” Biochem. J. (2004) 384, 19–24.
- Kang, J.W. et al. “Downregulation of PLK1 expression in kaempferol-induced apoptosis of MCF-7 cells.” Eur. J. Pharmacol. (2009) 611, 17–21.
Safety & Handling
- Signal Word: Danger
-
Hazard Statements:
- H301 – Toxic if swallowed
- H341 – Suspected of causing genetic defects
-
Precautionary Statements:
- P280 – Wear protective gloves/protective clothing/eye protection
- P308 + P313 – If exposed or concerned, seek medical attention
- P405 – Store locked up
- Classification: Acute Oral Toxicity Cat. 3 | Germ Cell Mutagenicity Cat. 2
The Thermo Scientific™ Kaempferol (≥97%) is a research-grade flavonoid with diverse biochemical properties, including enzyme inhibition, antioxidant defense, and apoptosis induction.
With >97% purity and consistent analytical verification, it is a trusted reagent for oncology, enzymology, pharmacology, and oxidative stress research.