0
Specifications:
| Application | Apoptosis | ||
| Storage Temperature | 2-8°C | ||
| Product Type | Biochemical Reagent | Forms | Solid |
| Product Brand | Thermo Fisher Scientific™, thermo Scientific | ||
| Product Grade | Molecular Biology | Formula | C₁₅H₁₀O₆ |
Thermo Scientific™ Kaempferol (≥98%) is a naturally occurring flavonoid compound with potent antioxidant, anti-inflammatory, and anticancer properties. It is widely used in biochemical and pharmacological research as an inhibitor of fatty acid synthase (FASN), cyclooxygenase-1 (COX-1), and topoisomerase I (Topo I).
Kaempferol has been shown to induce caspase-9–mediated apoptosis in various cancer cell lines through downregulation of polo-like kinase 1 (PLK1). It also exhibits antioxidant activity, blocks EGF-induced histone H3Ser10 phosphorylation, and reduces osteoclastic bone resorption in vitro, making it an important compound in oncology, biochemistry, and cell signaling research.
Key Features
- High Purity: >98% (HPLC) confirmed.
- Potent Enzyme Inhibitor: Inhibits FASN, COX-1, and Topoisomerase I activity.
- Apoptosis Induction: Activates caspase-9–mediated apoptosis via PLK1 downregulation.
- Antioxidant and Anti-inflammatory: Reduces oxidative stress and modulates cell signaling.
- Bone Research Utility: Inhibits osteoclastic bone resorption in vitro.
- Light-Sensitive Solid: Store in a dry, cool, and dark environment.
- Research Use Only (RUO): Not for diagnostic or therapeutic applications.
Chemical Identifiers
| Property | Value |
|---|---|
| CAS Number | 520-18-3 |
| IUPAC Name | 3,5,7-trihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one |
| Synonyms | Kaempferol, Rhamnolutein, Flavonol compound |
| Molecular Formula | C₁₅H₁₀O₆ |
| Molecular Weight | 286.24 g/mol |
| InChI Key | YDJHCGJRVQQCOM-UHFFFAOYSA-N |
| SMILES | C1=CC(=CC=C1C2=CC(=O)C3=C(O2)C(=C(C=C3O)O)O)O |
Specifications
| Parameter | Specification |
|---|---|
| Purity (HPLC) | >98.0% |
| Form | Solid |
| Appearance | Yellow crystalline solid |
| Proton NMR | Consistent with structure |
| Solubility | Soluble in DMSO or ethanol (up to 100 mM) |
| Storage Conditions | Cool, dry, light-protected place |
| Stability | Light-sensitive; avoid oxidizing agents |
| Packaging | Glass vial |
| Intended Use | Research Use Only (RUO) |
Applications
- Cancer Research: Induces apoptosis and inhibits tumor cell proliferation.
- Enzyme Inhibition Studies: Targets FASN, COX-1, and Topoisomerase I.
- Bone Biology: Attenuates osteoclast differentiation and bone resorption.
- Antioxidant and Anti-inflammatory Research: Used in oxidative stress and inflammation models.
- Signal Transduction: Studies involving EGF signaling and histone phosphorylation.
- Mitochondrial Function: Investigates activation of mitochondrial calcium uniporters.
References
- Montero, M. et al. “Direct activation of the mitochondrial calcium uniporter by plant flavonoids.” Biochem. J. (2004), 384, 19–24.
- Kang, K. et al. “Downregulation of PLK-1 expression in kaempferol-induced apoptosis of MCF-7 cells.” Eur. J. Pharmacol. (2009), 611, 17–21.
Safety & Handling
- Signal Word: Danger
-
Hazard Statements:
- H301 – Toxic if swallowed
- H341 – Suspected of causing genetic defects
- Precautions: P201, P264, P280, P301+P330+P331, P308+P313, P405
- Classification: Acute Oral Toxicity Cat. 3 | Germ Cell Mutagenicity Cat. 2
The Thermo Scientific™ Kaempferol (≥98%) is a high-purity natural flavonoid and enzyme inhibitor used in cancer, antioxidant, and signaling research.
With verified purity, well-documented biological activities, and consistent performance, this compound provides reliable results in apoptosis, enzyme inhibition, and oxidative stress studies across diverse biological models.