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Thermo Scientific™ Irinotecan Hydrochloride Trihydrate, 99%
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Topoisomerase I Inhibitor and Cytotoxic Camptothecin Analogue
Specifications:
| Application | cell Signalling, Apoptosis | ||
| Storage Temperature | -20°C | ||
| Product Type | Biochemical Reagent | Forms | Solid |
| Product Brand | Thermo Fisher Scientific™, thermo Scientific | ||
| Product Grade | Molecular Biology | Formula | C₃₃H₄₅ClN₄O₉ |
Thermo Scientific™ Irinotecan Hydrochloride Trihydrate (≥99%) is a semisynthetic camptothecin derivative and a potent topoisomerase I inhibitor used in oncology and pharmacological research.
As a prodrug of the active metabolite SN-38, irinotecan interferes with DNA replication and transcription by stabilizing the cleavable complex between DNA and topoisomerase I, resulting in DNA strand breaks and apoptosis in proliferating cells.
This reagent-grade compound is ideal for drug discovery, cytotoxicity studies, and mechanistic cancer research.
Key Features
- High Purity: ≥99% verified by analytical testing.
- Topoisomerase I Inhibitor: Induces DNA strand breaks through enzyme–DNA complex stabilization.
- Camptothecin Derivative: Functions as a model compound for antitumor mechanism studies.
- Research-Grade Quality: Suitable for biochemical and cell-based assays.
- Form: White to off-white crystalline powder.
- Solubility: Soluble in water and organic solvents.
- Storage: Store in a cool, dry, well-ventilated place.
- Research Use Only (RUO): Not intended for human or animal therapeutic use.
Chemical Identifiers
| Property | Value |
|---|---|
| Chemical Name (IUPAC) | Hydrogen (19S)-10,19-diethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.0²,¹¹.0⁴,⁹.0¹⁵,²⁰]henicosa-1(21),2(11),3,5,7,9,15(20)-heptaen-7-yl [1,4′-bipiperidine]-1′-carboxylate trihydrate chloride |
| Synonyms | Irinotecan hydrochloride trihydrate; CPT-11; Camptothecin-11 |
| CAS Number | 136572-09-3 |
| Molecular Formula | C₃₃H₄₅ClN₄O₉ |
| Molecular Weight | 677.19 g/mol |
| InChI Key | KLEAIHJJLUAXIQ-JDRGBKBRSA-N |
Specifications
| Parameter | Specification |
|---|---|
| Purity (HPLC) | ≥99% |
| Form | Powder or crystalline solid |
| Color | White to off-white |
| Mechanism of Action | Topoisomerase I inhibition leading to DNA damage and apoptosis |
| Solubility | Soluble in water and organic solvents |
| Storage Conditions | Store in a cool, dry place |
| Packaging | Glass bottle |
| Intended Use | Research Use Only (RUO) |
Applications
- Cancer and Oncology Research: Investigation of DNA replication, repair, and apoptosis mechanisms.
- Pharmacology: Model compound for studying topoisomerase I inhibitors and camptothecin derivatives.
- Molecular Biology: Studies involving DNA strand cleavage and replication stress.
- Drug Development: Screening and characterization of novel cytotoxic and prodrug analogues.
- Cell Biology: Evaluation of irinotecan-induced cytotoxicity in tumor cell lines.
The Thermo Scientific™ Irinotecan Hydrochloride Trihydrate, 99% is a high-purity, research-grade camptothecin analogue used for studying DNA damage, apoptosis, and antitumor mechanisms.
By targeting topoisomerase I, it serves as a reference compound in chemotherapy research, drug development, and cell-based cytotoxicity assays, offering reliable performance for advanced molecular and pharmacological studies.
- Pack Size: 250mg 100 mg