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Thermo Scientific™ (+)-Camptothecin, 98%
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Cytotoxic antitumor agent that inhibits topoisomerase I
Specifications:
| Application | Cell Analysis, Apoptosis | ||
| Storage Temperature | -20°C | ||
| Product Type | Biochemical Reagent | Forms | Solid |
| Product Brand | Thermo Fisher Scientific™, thermo Scientific | ||
| Product Grade | Molecular Biology | Formula | C₂₀H₁₆N₂O₄ |
Thermo Scientific™ (+)-Camptothecin (≥98%) is a potent DNA topoisomerase I inhibitor used extensively in cancer research, pharmacology, and molecular biology.
Derived originally from the Chinese tree Camptotheca acuminata, this natural alkaloid exhibits strong cytotoxic activity by stabilizing the DNA-topoisomerase I complex, resulting in DNA damage and apoptosis in proliferating cells.
Camptothecin serves as a key reference compound for the development of several clinically important anticancer agents, including irinotecan and topotecan.
Key Features
- High Purity: ≥97.5% by HPLC.
- Powerful Topoisomerase I Inhibitor: Induces DNA damage by preventing re-ligation of cleaved DNA strands.
- Research Grade Compound: Ideal for cell-based assays, cytotoxicity testing, and mechanistic oncology studies.
- Stable Formulation: Yellow crystalline powder with ≤1.0% loss on drying.
- Spectral Identity Confirmed: Infrared spectrum conforms to specification.
- Supplied in Glass Bottles: Ensures compound stability and chemical integrity.
- Research Use Only (RUO): Not for therapeutic or diagnostic use.
Chemical Identifiers
| Property | Value |
|---|---|
| IUPAC Name | (19S)-19-ethyl-19-hydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.0²,¹¹.0⁴,⁹.0¹⁵,²⁰]henicosa-1(21),2(11),3,5,7,9,15(20)-heptaene-14,18-dione |
| Synonyms | (+)-Camptothecin, 20(S)-Camptothecin, D-Camptothecin, Camptothecine, CPT |
| CAS Number | 7689-03-4 |
| Molecular Formula | C₂₀H₁₆N₂O₄ |
| Molecular Weight | 348.35 g/mol |
| InChI Key | VSJKWCGYPAHWDS-FQEVSTJZSA-N |
| SMILES | CC[C@@]1(O)C(=O)OCC2=C1C=C1N(CC3=C1N=C1C=CC=CC1=C3)C2=O |
Specifications
| Parameter | Specification |
|---|---|
| Purity (HPLC) | ≥97.5% |
| Form | Powder |
| Color | Yellow |
| Infrared Spectrum | Conforms to reference standard |
| Loss on Drying | ≤1.0% |
| Storage Conditions | Store in a cool, dry place, protected from light |
| Packaging | Glass bottle |
| Intended Use | Research Use Only (RUO) |
Applications
- Cancer Research: Mechanistic studies on DNA damage, apoptosis, and cell cycle arrest.
- Pharmacology: Reference compound for anticancer drug discovery.
- Molecular Biology: Used to investigate topoisomerase I–DNA interaction and stability.
- Drug Development: Precursor for derivatives such as irinotecan (CPT-11) and topotecan.
- Cell Biology: Induction of controlled DNA strand breaks for cellular response studies.
References
- Wall, M.E. et al. “Camptothecin: Discovery of a new antitumor agent.” Cancer Chemother Rep (1966) 50(6): 261–270.
- Pommier, Y. et al. “Mechanism of action of topoisomerase I inhibitors.” Biochim. Biophys. Acta (1998) 1400, 83–105.
The Thermo Scientific™ (+)-Camptothecin, 98% is a high-purity reference compound essential for cancer research, cytotoxicity testing, and DNA repair studies.
As a well-characterized topoisomerase I inhibitor, it remains a cornerstone in the study of DNA damage and apoptosis pathways and serves as a key building block for modern anticancer drug development.
- Pack Size: 1g 100 mg