Sigma-Aldrich™ Fmoc-Trp(Boc)-OH ≥97.0% (HPLC), for peptide synthesis

Fmoc-Trp(Boc)-OH is a high-purity, selectively protected tryptophan derivative used in Fmoc-based solid-phase peptide synthesis (SPPS). It features an Fmoc-protected α-amino group and Boc protection on the indole nitrogen of tryptophan, enabling controlled peptide elongation while helping to reduce unwanted side reactions involving the indole side chain.

This reagent is widely used in custom peptide synthesis, pharmaceutical research, proteomics, drug discovery, enzyme-substrate studies, structural biology, protein engineering, and bioorganic chemistry. Tryptophan-containing peptides are particularly valuable in studies involving protein folding, hydrophobic interactions, fluorescence, and peptide–receptor interactions.

Key Features

Chemical Properties & Identifiers

Applications

Fmoc-Trp(Boc)-OH is suitable for:

• Fmoc-based solid-phase peptide synthesis
• Incorporation of tryptophan residues into synthetic peptides
• Custom peptide synthesis and peptide modification
• Peptide-based pharmaceutical and drug discovery research
• Enzyme-substrate and inhibitor studies
• Protein engineering and structural biology research
• Fluorescence-related peptide and protein studies
• Bioorganic chemistry and peptidomimetic synthesis
• Synthesis of tryptophan-containing therapeutic peptide analogs

Ordering Information

Storage & Handling

Store at 2–8 °C in a dry, tightly sealed container. Protect from moisture, oxidation, and extreme temperatures. Handle in a suitable laboratory environment using appropriate personal protective equipment, including gloves, lab coat, and safety goggles.

Research Use Statement

For Research Use Only (RUO). Not intended for diagnostic or therapeutic use.