Thermo Scientific™ Vanquish™ Binary Pump F

The Thermo Scientific™ Vanquish™ Binary Pump F is a high-performance UHPLC pump designed to deliver exceptional flow precision, fast gradient formation, and unmatched analytical reproducibility across nano-, capillary-, micro-, and analytical-flow chromatography applications. As part of the Vanquish™ UHPLC platform, the Pump F brings together advanced solvent delivery technology, robust engineering, and intelligent system control to support demanding analytical workflows in pharmaceutical, biopharmaceutical, environmental, food safety, and research laboratories.

Engineered for laboratories requiring high pressure capability, accurate solvent proportioning, and long-term reliability, the Vanquish Binary Pump F provides a pressure range of 2–103 MPa (up to 1000 bar / 15,000 psi) and a maximum flow rate of 8 mL/min, making it suitable for a wide range of LC methods—from traditional HPLC gradients to fast UHPLC separations.

Key Performance Advantages

1. Excellent Flow Accuracy & Precision

The pump integrates ultra-precise piston drives and advanced active flow control technology to ensure:

• Smooth, pulsation-free flow delivery
• Accurate low-flow performance for nano- and capillary LC
• Reproducible micro- and analytical-flow gradients
  This results in highly stable baselines, improved detector sensitivity, and consistent chromatographic retention times.

2. State-of-the-Art Gradient Formation

The Vanquish Binary Pump F supports high-pressure gradient proportioning, enabling rapid method changes, steep gradients, and excellent mixing efficiency. With up to 6 solvent channels, the system offers flexibility for multi-solvent workflows and complex method development.

3. Built-In Solvent Degassing

For analytical-flow applications, an integrated solvent degasser enhances flow stability by eliminating dissolved gases that may cause baseline noise, bubble formation, or flow disturbances. This ensures optimal performance with sensitive UV, diode array, and MS detectors.

4. Engineered for Durability & Uptime

All fluidic components are designed for high mechanical stability, long operational life, and minimal maintenance. The pump’s rugged design helps reduce total cost of ownership while ensuring maximum system uptime—even under continuous daily use in high-throughput labs.

5. Easy, Leak-Free Fluidic Setup

The pump incorporates Thermo Scientific™ Viper™ and nanoViper™ fingertight fittings, which provide:

• Torque-controlled, leak-free connections
• Audible and tactile confirmation when properly tightened
• Simplified installation without tools
  This reduces downtime, eliminates common fitting errors, and ensures reliable, high-pressure performance.

Flow & Pressure Capabilities

Different Vanquish binary pump models are available for various pressure-flow combinations; the Pump F offers the ideal balance for mainstream UHPLC:

The Pump F is designed for laboratories that require high-pressure capability with higher flow rates, suitable for robust UHPLC and HPLC methods.

Applications

• Pharmaceutical and biopharmaceutical analysis
• QC and routine identity/impurity testing
• Environmental and food safety chromatography
• Research and method development labs
• LC–MS workflows requiring high solvent delivery precision
• Nano-, capillary-, micro-flow separations
• Analytical-flow UHPLC separations

Specifications

The Thermo Scientific™ Vanquish™ Binary Pump F delivers smooth, precise, and stable flow for UHPLC performance up to 1000 bar with a maximum flow rate of 8 mL/min. Equipped with SmartFlow™/ProFlow™ technologies, integrated solvent degassing, and Viper fingertight fittings, it provides industry-leading reliability, gradient accuracy, and chromatographic reproducibility for demanding analytical workflows.