Thermo Scientific™ Sodium dodecyl sulfate (SDS), 95+%

High-Purity Anionic Detergent for Molecular Biology and Protein Biochemistry

Sodium dodecyl sulfate (SDS), also known as sodium lauryl sulfate, is a widely used anionic surfactant with powerful solubilizing and denaturing properties. Supplied by Thermo Scientific™ with ≥95% purity, this reagent-grade SDS is designed for critical laboratory and research applications, particularly in protein analysis, molecular biology, and cell lysis protocols.

Its amphiphilic molecular structure, consisting of a hydrophobic 12-carbon alkyl chain and a hydrophilic sulfate group, allows SDS to interact strongly with biological membranes and proteins, disrupting their structure and rendering them more accessible for analysis and manipulation.

Key Applications

• SDS-PAGE: Standard in protein separation by molecular weight via electrophoresis.
• Protein Extraction & Denaturation: Efficient solubilization and linearization of proteins for downstream analysis.
• Nucleic Acid Isolation: Facilitates cell lysis and disruption of membranes during DNA/RNA extraction.
• Cell Biology & Hybridization Techniques: Used in protocols including PCR preparation, Southern/Northern blotting, and inactivation of enveloped viruses.
• Biocontrol Studies: Used as a reference compound in assays evaluating bacterial elicitation of systemic plant resistance.

Biochemical & Physiological Actions

• Forms stable complexes with proteins via hydrophobic interactions.
• Disrupts secondary and tertiary protein structures, enabling analysis based on size rather than conformation.
• Solubilizes cellular and membrane components for extraction and purification.
• Influences hydrodynamic behavior of protein complexes, correlating with peptide chain length.

Specifications

Features & Benefits

✅ Reliable Consistency: Reagent grade with guaranteed ≥95% purity for reproducibility

✅ Low Metal Contamination: Ensures compatibility with sensitive molecular and biochemical techniques

✅ Versatile Research Utility: Supports diverse workflows from electrophoresis to cell disruption

✅ Compatible with Common Protocols: Integrates easily into standard SDS-PAGE, nucleic acid extraction, and hybridization assays

Thermo Scientific™ SDS (≥95%) is an essential, high-quality detergent trusted across biochemical and molecular biology laboratories. Its unique amphipathic properties make it indispensable in protocols requiring protein solubilization, membrane disruption, and electrophoretic separation. A critical reagent for ensuring accurate and reproducible results in protein analysis and nucleic acid workflows.