Thermo Scientific™ Diethyldithiocarbamic acid, sodium salt trihydrate, ACS reagent

Thermo Scientific™ Sodium Diethyldithiocarbamate Trihydrate is a high-purity, ACS-grade reagent with diverse applications in organic synthesis, coordination chemistry, and biochemical analysis. As a versatile chelating agent and spin trap, this compound is particularly valuable for studies involving nitric oxide (NO) detection, metal complexation, and enzyme inhibition.

It serves as a precursor in organotin, ruthenium, and polymer syntheses, and functions effectively as a copper chelator in biochemical assays. In bioanalytical chemistry, it is widely used in electron spin resonance (ESR) applications to trap free radicals and quantify copper in biological matrices.

Key Features & Benefits

• ✅ ACS Reagent Grade – High purity suitable for analytical and synthetic use
• ✅ Chelating Agent – Strong complexation with transition metals including Cu, Fe, and Sn
• ✅ Spin Trap for NO – Facilitates detection of nitric oxide in tissue samples via Fe²⁺ complexes
• ✅ Versatile in Synthesis – Used in organometallic, polymer, and radical precursor chemistry
• ✅ Enzyme Inhibitor – Inhibits superoxide dismutase and other oxidases
• ✅ Stable Solid Form – Trihydrate offers enhanced handling and storage stability

Applications

• Nitric Oxide Detection
  • Acts as a spin trap (in conjunction with Fe²⁺) for detecting NO in brain, liver, and kidney tissues
  • Enables simultaneous ESR measurement of NO* and partial oxygen pressure (pO₂)
• Synthesis Applications
  • Synthesis of cis-dichlorobis(N,N-diethyldithiocarbamato)tin(IV)
  • Used as an alternative to xanthates for carbamoyl radical generation
  • Precursor to poly(thienylene vinylene), a conductive polymer
  • Intermediate for dichlorotetrakis(dimethyl sulfoxide)ruthenium(II) complex
• Biochemical Assays
  • Copper chelation for quantifying metal in biological materials
  • Inhibits macrophage nitric oxide synthase (iNOS)
  • Inhibits superoxide dismutase, ascorbate oxidase, and other redox enzymes

Technical Specifications

The Thermo Scientific™ Sodium Diethyldithiocarbamate Trihydrate is a multi-functional reagent that plays a crucial role in both synthetic and analytical chemistry. From NO detection and radical trapping to metal complexation and enzyme inhibition, its broad utility and reliable ACS-grade purity make it a trusted component in advanced research protocols.