Apollo Trifluoroacetic acid 99,9%, Biochemical Grade

Specifications:

ADR Classification: 8 (Corrosive), I (Substance causing severe chemical burns)

UN Number: 2699

GHS Classification: GHS05 (Corrosive), GHS07 (Harmful)

Trifluoroacetic Acid (TFA, 99.5%) is a highly volatile organofluorine compound used as a reagent in organic synthesis. Its unique physicochemical properties, such as its high volatility, solubility in organic solvents, and strong acidic nature, make it ideal for a wide range of acid-catalyzed reactions. This includes processes like ring-opening of epoxides, biomimetic cyclization, Cope rearrangements, and natural product synthesis.

TFA's volatility provides the advantage of easy product isolation by evaporation, which reduces the need for neutralization or an extractive workup typically required by less volatile acids such as sulfuric acid or p-toluenesulfonic acid.

This versatile fluorinated acid is used in polymer chemistry, synthetic chemistry, and catalytic processes due to its reactivity and high solubility in a variety of organic solvents.

Key Features:

1. High Purity (99.5%):
   • TFA 99.5% is suitable for use in sensitive organic reactions and analytical procedures requiring high-purity reagents.
2. Strong Acidic Strength:
   • Trifluoroacetic acid’s strong acidity makes it an ideal catalyst for acid-catalyzed reactions in organic chemistry.
3. High Volatility:
   • TFA's high volatility allows for easy product isolation by evaporation, streamlining the synthesis process and eliminating the need for complex extraction methods.
4. Solubility in Organic Solvents:
   • The solvent properties of TFA make it ideal for use in a wide range of organic solvents, enabling its use in various reactions where other acids may not be as effective.
5. Versatile Reagent:
   • It can be used for the cleavage of protecting groups, oxidation reactions, trifluoromethylation, and polymerization processes.
6. Environmental Consideration:
   • As a greener alternative, TFA is highly effective in reducing waste and improving reaction yields compared to more hazardous alternatives.

Applications:

1. Cleavage of Protecting Groups:
   • TFA is commonly used in removing protecting groups such as N-Boc, benzyl ethers, and t-butyl ethers in organic synthesis, particularly in peptide synthesis.
2. Baeyer-Villiger Oxidation:
   • TFA is a key reagent in Baeyer-Villiger oxidation reactions, often in combination with sodium percarbonate.
3. C-H Trifluoromethylation:
   • It is utilized for trifluoromethylation of arenes, introducing a CF₃ group into the aromatic ring, a critical step in the preparation of fluorinated compounds.
4. Polymer Chemistry:
   • Used as a solvent and catalyst in various polymerization reactions, including the synthesis of fluoropolymers and high-performance materials.
5. Synthesis of Amino Group-Containing Cyanine Dyes:
   • TFA is involved in the synthesis of cyanine dyes used in biological imaging and fluorescent labeling.
6. Beckmann Rearrangement:
   • TFA is used as a catalyst in the Beckmann rearrangement to synthesize ε-caprolactam, the precursor for nylon-6.

Packaging Options:

Storage:

• Store at ambient temperature in a cool, dry place to maintain its purity and reactivity.

Apollo Scientific Trifluoroacetic Acid (TFA) is an essential reagent for organic synthesis, particularly for cleaving protecting groups, oxidation reactions, and trifluoromethylation. With its high purity, volatility, and versatility, it is ideal for biochemical research, pharmaceutical production, and polymer chemistry.