Liofilchem® Azithromycin AZM, Antimicrobial Susceptibility Discs, 15 μg

The Liofilchem® Azithromycin (AZM) Antimicrobial Susceptibility Discs, 15 µg are high-quality diagnostic tools designed to evaluate the susceptibility of bacterial isolates to azithromycin. These discs are an essential component of antimicrobial susceptibility testing (AST), enabling healthcare professionals and researchers to determine the effectiveness of azithromycin against bacterial pathogens.

Key Features:

1. Standardized Dosage:
   • Each disc is impregnated with 15 µg of azithromycin, ensuring consistent and accurate results in susceptibility testing.
2. High Quality:
   • Manufactured under stringent quality controls to ensure uniform drug concentration and reliable results.
3. Ready-to-Use:
   • Supplied in pre-packaged cartridges for easy application and minimized contamination risk.
4. Regulatory Compliance:
   • Conforms to standards set by CLSI (Clinical and Laboratory Standards Institute) and EUCAST (European Committee on Antimicrobial Susceptibility Testing) for susceptibility testing.
5. Wide Application:
   • Suitable for testing gram-positive and gram-negative bacteria, particularly pathogens causing respiratory and skin infections.

Applications:

1. Clinical Diagnostics:
   • Determines the susceptibility of pathogens to azithromycin, aiding in appropriate antibiotic therapy selection.
2. Research and Development:
   • Supports the study of bacterial resistance patterns in microbiological research.
3. Pharmaceutical Quality Control:
   • Ensures the efficacy of azithromycin in clinical and industrial microbiology settings.
4. Public Health Surveillance:
   • Monitors antimicrobial resistance trends in bacterial pathogens, contributing to infection control strategies.

Use Cases:

1. Respiratory Infections:
   • Identifies the susceptibility of Streptococcus pneumoniae or Haemophilus influenzae to azithromycin for managing respiratory tract infections.
2. Skin and Soft Tissue Infections:
   • Assesses the activity of azithromycin against pathogens like Staphylococcus aureus, including methicillin-sensitive strains.
3. Sexually Transmitted Infections:
   • Determines the effectiveness of azithromycin against Neisseria gonorrhoeae or Chlamydia trachomatis.
4. Enteric Pathogens:
   • Tests susceptibility in enteric pathogens such as Salmonella spp. and Shigella spp., often implicated in gastrointestinal infections.

Specifications:

Testing Procedure:

1. Preparation:
   • Inoculate a Mueller-Hinton agar plate with a standardized bacterial suspension (e.g., 0.5 McFarland standard).
2. Disc Application:
   • Place the azithromycin disc on the agar surface using sterile forceps or a disc dispenser.
3. Incubation:
   • Incubate the plate at 35°C for 16–18 hours in an aerobic environment.
4. Result Interpretation:
   • Measure the diameter of the zone of inhibition around the disc.
   • Compare results to CLSI/EUCAST interpretative criteria to classify the organism as susceptible (S), intermediate (I), or resistant (R).

Advantages:

1. Accurate Results:
   • Provides reliable and reproducible susceptibility data for informed antibiotic therapy decisions.
2. Easy Handling:
   • Pre-packaged format ensures convenient application and reduced contamination risks.
3. Broad Compatibility:
   • Compatible with a wide range of bacterial pathogens and laboratory workflows.
4. Contributes to Resistance Management:
   • Supports efforts to track and mitigate antimicrobial resistance trends.

Storage and Handling:

• Store at 2°C to 8°C in a dry environment, away from light and moisture.
• Ensure discs are used before the expiration date indicated on the label.
• Avoid prolonged exposure to room temperature to maintain drug potency.

Product Details:

The Liofilchem® Azithromycin (AZM) Antimicrobial Susceptibility Discs, 15 µg are a reliable, ready-to-use tool for assessing bacterial susceptibility to azithromycin. Their high quality and ease of use make them indispensable for clinical diagnostics, research, and public health surveillance.