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Liofilchem® Trimethoprim-sulfamethoxazole Antimicrobial Susceptibility Disc, SXT, 25 µg
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Specifications:
| Application | Microbiology |
| Storage Temperature | 2-8°C |
| Product Type | Antibiotic Disc |
| Product Brand | Liofilchem |
| Product Grade | Microbiology grade |
The Liofilchem® Trimethoprim-Sulfamethoxazole Antimicrobial Susceptibility Discs are precision tools designed for the Kirby-Bauer disc diffusion method to determine bacterial susceptibility to Trimethoprim-Sulfamethoxazole (TMP-SMX). Available in two specific drug concentrations—25 µg and 2.5 µg—these discs are ideal for testing Gram-positive and Gram-negative bacterial isolates in clinical diagnostics and research.
Key Features
1. Two Drug Concentrations
- 25 µg: Standard concentration for routine susceptibility testing.
- 2.5 µg: Lower concentration for specialized testing or research applications.
2. Accurate and Reliable
- Produces well-defined zones of inhibition for clear, reproducible interpretation of results.
3. Target Pathogens
- Effective against a range of pathogens, including:
- Gram-negative bacteria: E. coli, Klebsiella spp., Proteus spp., Salmonella spp., and Shigella spp.
- Gram-positive bacteria: Staphylococcus aureus (including MRSA), Streptococcus pneumoniae.
4. Therapeutic Combination
- Contains Trimethoprim and Sulfamethoxazole in a 1:19 ratio, mimicking clinical dosing for optimized testing accuracy.
5. Compliance with Global Standards
- Fully compliant with EUCAST, CLSI, and ISO guidelines for antimicrobial susceptibility testing.
Applications
1. Clinical Diagnostics
- Determine bacterial susceptibility to TMP-SMX for treating:
- Urinary tract infections (UTIs).
- Respiratory infections.
- Gastrointestinal infections.
- Skin and soft tissue infections.
2. Antibiotic Resistance Monitoring
- Identify resistance trends in Gram-positive and Gram-negative pathogens in healthcare and community settings.
3. Research and Development
- Investigate TMP-SMX efficacy and resistance mechanisms in experimental studies.
4. Surveillance Studies
- Monitor the spread of TMP-SMX resistance in multidrug-resistant organisms.
Specifications
| Parameter | Details |
|---|---|
| Antibiotic | Trimethoprim-Sulfamethoxazole |
| Disc Concentrations | 25 µg, 2.5 µg |
| Target Organisms | Gram-positive and Gram-negative bacteria |
| Testing Method | Kirby-Bauer disc diffusion |
| Compliance | EUCAST, CLSI, ISO standards |
| Storage Conditions | 2–8°C / -20°C |
How It Works
- Sample Preparation:
- Prepare bacterial suspension using 0.5 McFarland standard.
- Inoculation:
- Spread the bacterial suspension uniformly onto a Mueller-Hinton agar plate.
- Disc Placement:
- Place either 25 µg or 2.5 µg Trimethoprim-Sulfamethoxazole disc on the agar surface.
- Incubation:
- Incubate at 35–37°C for 16–18 hours.
- Result Interpretation:
- Measure the diameter of the zone of inhibition and compare to interpretive standards for TMP-SMX susceptibility.
Advantages
1. Precision
- Reliable results for both routine diagnostics and specialized research.
2. Flexible Applications
- Suitable for clinical labs and research institutions, with dual concentration options.
3. Quality Assured
- Manufactured under stringent quality controls to ensure uniform drug diffusion and performance.
4. Cost-Effective
- Ideal for high-throughput laboratories with standardized workflows.
Why Choose Liofilchem® Trimethoprim-Sulfamethoxazole Discs?
- Comprehensive Testing: Two concentrations provide flexibility for routine and advanced applications.
- Accuracy and Reliability: Trusted results for clinical diagnostics and resistance monitoring.
- Regulatory Compliance: Meets international standards for antimicrobial susceptibility testing.
The Liofilchem® Trimethoprim-Sulfamethoxazole Antimicrobial Susceptibility Disc (25 µg, 2.5 µg) is a reliable and versatile tool for evaluating bacterial sensitivity, aiding in effective treatment decisions and resistance surveillance.