Sigma-Aldrich Human Serum Heat Inactivated, from human male AB plasma, USA origin, sterile-filtered

Sigma-Aldrich™ Human Serum, Heat Inactivated, is a premium-grade, sterile-filtered biological supplement derived from pooled human male AB plasma of U.S. origin. This serum is heat-inactivated to eliminate complement activity, supporting sensitive cell types and immunological applications. It is widely used in mammalian cell culture systems, offering a rich mix of macromolecules, growth factors, carrier proteins, and nutrients that promote cell growth, viability, and functionality.

Pooled from multiple male donors of AB blood type, this serum minimizes the presence of natural antibodies (anti-A and anti-B), enhancing compatibility with a wide range of human cells. The product undergoes rigorous quality control testing for sterility, hemoglobin content, and endotoxin levels, ensuring batch-to-batch consistency for research applications.

Key Features & Benefits

• Human AB Plasma Source: Minimizes antibody interference—ideal for primary and immune cell culture.
• Heat Inactivated: Reduces complement-related cytotoxicity in sensitive cultures.
• Sterile-Filtered: Triple-filtered to ensure sterility for aseptic lab use.
• Endotoxin Tested: ≤10 EU/mL for use in endotoxin-sensitive assays.
• Nutrient-Rich Composition: Includes hormones, growth factors, attachment proteins, and lipids.
• Consistent Quality: Hemoglobin content ≤20 mg/dL; each lot tested and traceable.
• USA Origin: Ethically sourced from certified U.S. donors.

Applications

• Mammalian Cell Culture: Widely used as a supplement in serum-dependent cultures.
• Immune Research: Supports the culture of monocytes, macrophages, and PBMCs.
• Western Blotting: Used as a control in protein expression and antibody validation.
• In Vitro Modeling: Ideal for physiological and clinical relevance in human-based assays.

Specifications

Packaging Notes

Due to global supply constraints, bottle types and packaging (including shrink wrap) may vary by batch. These variations do not affect product sterility or integrity.

Regulatory Disclaimer

• For Research Use Only. Not for human or animal therapeutic use.
• France Importation: Regulated under Article L1211-1 of the French Public Health Code. Users in France must obtain import authorization (Article L1245-5-1 II).

Additional Notes

• Cloudy Appearance Is Normal: This product contains natural lipids; clear, lipid-free human serum is not available.
• Batch Consistency: Pooled human serum provides reduced lot-to-lot variability.

Available Sizes