Thermo Scientific™ Carboplatin (HPLC) 98.0%

Thermo Scientific™ Carboplatin is a platinum-based antineoplastic compound widely used in oncology and biochemical research. It belongs to the class of DNA cross-linking agents that interfere with DNA replication and repair, leading to apoptosis in rapidly dividing cells.

Carboplatin serves as a research-grade cytotoxic reagent and a model compound for studying platinum coordination chemistry, drug–DNA interactions, and the mechanism of action of platinum-based chemotherapeutics.

Key Features

• High Purity: ≥98.0% by HPLC.
• Platinum-based Antitumor Agent: Used in research on cancer treatment mechanisms.
• Mode of Action: Forms intra- and inter-strand DNA crosslinks, inhibiting DNA synthesis and replication.
• Solubility: Readily soluble in water for easy preparation of aqueous solutions.
• Research Use: Ideal for studies on platinum coordination chemistry and DNA-binding agents.
• Physical Form: Fine white to off-white crystalline powder.
• Storage: Store in a cool, dry, and well-ventilated area; tightly sealed.
• Research Use Only (RUO): Not for diagnostic or therapeutic use.

Chemical Identifiers

Specifications

Applications

• Cancer Research: Investigation of carboplatin’s cytotoxic and DNA-binding mechanisms.
• Molecular Biology: Studies of DNA crosslinking and repair pathways.
• Pharmacology: Model compound for platinum-based drug studies.
• Biochemical Research: Development of novel metal-coordination therapeutic agents.
• Structural Biology: Crystallographic and chemical analysis of platinum–protein complexes.

References

1. Jakacki, R.I. et al., “Outcome and Prognostic Factors for Children With Supratentorial Primitive Neuroectodermal Tumors Treated With Carboplatin During Radiotherapy.” Pediatr. Blood Cancer (2015), 62(5), 776–783.
2. Boal, A.K. & Rosenzweig, A.C., “Response to Crystallography and Chemistry of Protein Complexes with Cisplatin and Carboplatin.” Acta Crystallogr. Sect. D (2015), 71, 1984–1986.

The Thermo Scientific™ Carboplatin (≥98%) is a high-purity platinum-based compound used as a research-grade antitumor and DNA crosslinking agent.

Valuable in studies of oncology, DNA repair, and coordination chemistry, this reagent offers reliable purity and performance for investigating the molecular mechanisms of platinum-based chemotherapy.