Thermo Scientific™ Nifedipine 98+%

Thermo Scientific™ Nifedipine is a highly pure, pharmaceutical-grade dihydropyridine calcium channel blocker, widely used in neuroscience, cardiovascular, oncology, and toxicology research. This compound selectively blocks L-type voltage-gated calcium channels, making it a valuable reference molecule in studies on calcium signaling, vascular smooth muscle relaxation, and neuronal protection.

Supplied as a yellow crystalline powder with ≥98% purity confirmed via HPLC, this compound offers exceptional performance in both in vitro and ex vivo model systems. It is stable under refrigeration and suitable for biochemical, molecular, and pharmacological applications.

Key Specifications

Applications in Research

Nifedipine is a well-characterized pharmacological agent extensively used in a variety of research domains:

• Neurophysiology:
  Used to study calcium influx through R-type and L-type channels in myenteric and CNS neurons (e.g., guinea pig small intestine and dopaminergic neurons).
• Neuroprotection Studies:
  Demonstrates protective effects on cholinergic and dopaminergic neurons and shows promise in models of Parkinson's and glioblastoma, where it induces apoptosis.
• Vascular & Cardiovascular Research:
  Widely studied for its vasodilatory and antihypertensive properties due to its inhibition of voltage-gated L-type Ca²⁺ channels.
• Oxidative Stress and Inflammation:
  Reported to suppress TNF-α and MIP-2, and exhibit antioxidant activity in immune-modulatory studies.
• Pharmacokinetic Interactions:
  Investigated in drug interaction studies with hypoglycemic agents in HUVECs (human umbilical vein endothelial cells).
• Gene Expression:
  Known to inhibit the ADORA2A gene (adenosine A2a receptor), linking calcium signaling with purinergic receptor biology.

Biochemical and Pharmacological Actions

• Mechanism: L-type calcium channel antagonist
• Receptor Targets: CaV1.2 channels (α1C subunit), ADORA2A receptor
• Activity: Vasodilation, neuron protection, anti-inflammatory
• Functional Categories:
  • Calcium channel blocker
  • Antihypertensive
  • Neuroprotective compound
  • Oxidative stress modulator
  • Small molecule probe for ADME-Tox studies

Key Research Uses

• ADME/Tox Screening
• Signal Transduction
• Calcium Channel Electrophysiology
• Cyclic Nucleotide Pathways (CNG, HCN)
• Cancer Cell Apoptosis Studies
• Antioxidant Activity in Neurodegeneration

Thermo Scientific™ Nifedipine (≥98%) is a well-characterized reference standard for L-type calcium channel inhibition, making it a valuable reagent for electrophysiology, inflammation, cardiovascular, and neuroprotective research. With high chemical purity, known biological effects, and established literature references, it serves as a cornerstone for calcium signaling and pharmacology studies.