Thermo Scientific™ Chlorosulphuric acid ≥99%

Chlorosulfonic acid (HSO₃Cl) is a strong acid with multiple applications as a sulfonating, dehydrating, oxidizing, and chlorinating agent. Synthesized on an industrial scale by reacting sulfur trioxide (SO₃) with dry hydrogen chloride gas (HCl) in an equimolar ratio, this chemical is widely used in organic synthesis, particularly for electrophilic reactions. Chlorosulfonic acid is considered a superior agent for electrophilic olefin cyclization compared to other sulfonic acids.

This highly reactive acid has recorded infrared spectra in the range of 4000-400 cm⁻¹ in the solid, liquid, and gaseous states. It is typically used in applications requiring strong sulfonation capabilities.

Applications:

1. Synthesis of Ionic Liquids: Used in the synthesis of di-n-butyl ammonium chlorosulfonate, a secondary amine ionic liquid with various industrial and research applications.
2. Polymer Modification: Employed in the preparation of sulfonated polyethersulfone (SPES), which enhances the hydrophilic properties of the polymer, making it more suitable for applications like membranes and separation processes.
3. Biomaterial Enhancement: Used to attach sulfate groups to silk fibroin, improving its anticoagulant properties, with potential applications in biomedical engineering.
4. Synthesis of Substituted Coumarins: Acts as a catalyst in the von Pechmann condensation reaction between phenol and β-ketoesters, facilitating the synthesis of coumarins, which are valuable in medicinal chemistry.
5. Biginelli Reaction Catalysis: Chlorosulfonic acid serves as an acid catalyst in the Biginelli reaction to prepare 3,4-dihydropyrimidines, which are important heterocyclic compounds in drug synthesis.

Key Features:

• Sulfonating, Dehydrating, and Chlorinating Agent: Ideal for electrophilic reactions and various organic syntheses.
• High Purity: ≥99% purity ensures consistent and reliable results in chemical processes.
• Versatile Reagent: Suitable for a range of organic synthesis applications, including polymer modifications, ionic liquid synthesis, and advanced organic reactions.
• Reliable Performance: High reactivity and electrophilic properties make it effective in multiple applications across chemical and biochemical industries.

Specifications:

Applications in Organic Synthesis:

• Sulfonation: Chlorosulfonic acid is widely used in the sulfonation of various organic compounds, including aromatic hydrocarbons and olefins.
• Electrophilic Olefin Cyclization: Acts as a more effective electrophilic cyclization agent in comparison to other sulfonic acids, making it essential for specialized organic reactions.

Thermo Scientific™ Chlorosulfonic Acid (≥99%) is an essential reagent for organic synthesis, offering superior sulfonation and chlorination capabilities. With a wide range of applications, including the synthesis of ionic liquids, the modification of polymers, and biomaterial enhancement, it is a versatile and powerful chemical used in both industrial processes and research applications. Its high purity and reliability ensure accurate results in various chemical and biochemical syntheses.