Thermo Scientific™ Vanquish™ Neo UHPLC System

The Thermo Scientific™ Vanquish™ Neo UHPLC System is a cutting-edge low-flow ultra-high-performance liquid chromatography (UHPLC) platform engineered to deliver maximum sensitivity, precision, and robustness for advanced LC-MS workflows. Designed to support nano-, capillary-, and micro-flow separations, the Vanquish Neo system sets a new benchmark for high-performance chromatography in omics research, biopharmaceutical analysis, and translational science.

Powered by ProFlow™ XR pump technology, the system provides active flow control across an ultra-wide range (1 nL/min to 100 μL/min), ensuring exceptional retention time precision and reproducibility. Its innovative 1500 bar (21,750 psi) pressure capability enables the use of longer columns and smaller particle sizes, significantly enhancing chromatographic resolution and peak capacity.

The integrated split-loop autosampler minimizes dispersion while improving injection precision, even for limited sample volumes, while advanced features such as SmartInject technology, vial bottom detection, and automated multi-wash procedures ensure high sensitivity, reduced carryover, and optimized system performance.

Key Features

• All-in-one nano-, capillary-, and micro-flow UHPLC system for LC-MS applications
• ProFlow™ XR pump technology delivers precise and stable flow control
• Ultra-wide flow range: 1 nL/min to 100 μL/min
• Maximum pressure of 1500 bar (21,750 psi) for high-efficiency separations
• Split-loop autosampler design reduces dispersion and enhances injection accuracy
• SmartInject technology improves retention time precision and ESI stability
• Vial bottom detection ensures accurate injection from limited sample volumes
• Automated multi-wash procedures minimize carryover for trace-level analysis
• Fast sample loading and equilibration for improved throughput
• Integrated system intelligence simplifies method development and operation
• User-friendly Vanquish interface for real-time monitoring and guided maintenance
• Seamless integration with Thermo Scientific LC-MS systems, including Orbitrap and triple quadrupole platforms
• ACT Ecolabel (Gold) for environmentally responsible laboratory operation

Applications

The Vanquish Neo UHPLC System is optimized for:

• Proteomics and deep proteome analysis
• Metabolomics and lipidomics workflows
• Biopharmaceutical characterization and peptide mapping
• Translational and clinical research
• High-sensitivity LC-MS analysis of low-abundance compounds
• Nano LC-MS workflows for limited sample volumes
• Quantitative and qualitative biomolecule analysis
• Drug discovery and development studies

Technical Specifications

Unique Advantages

The Vanquish Neo UHPLC System stands out as a highly versatile, low-flow chromatography platform that combines ultra-high pressure capability, precision flow control, and advanced automation into a single integrated system. Its ability to seamlessly operate across nano-, capillary-, and micro-flow regimes eliminates the need for multiple instruments, reducing laboratory complexity while maximizing flexibility.

The combination of ProFlow XR technology, SmartInject precision, and low-dispersion autosampler design ensures exceptional chromatographic performance, making it particularly valuable for high-sensitivity LC-MS workflows and omics research. Additionally, its ACT Ecolabel certification supports laboratories aiming to improve sustainability without compromising analytical performance.

The Thermo Scientific™ Vanquish™ Neo UHPLC System is a next-generation chromatography solution designed for laboratories that demand precision, sensitivity, and reliability in low-flow LC-MS applications. Whether used in proteomics, metabolomics, or biopharma research, it provides the performance and flexibility required to drive high-impact scientific discoveries.