0
Thermo Scientific™ Tamoxifen, 98%
Catalog No :
CAS Number :
Brand :
In Stock
Estrogen Receptor Antagonist | Antineoplastic Agent | Protein Kinase C Inhibitor
Specifications:
| Application | Life Science Applications | ||
| Storage Temperature | 2-8°C | ||
| Product Type | Biochemical Reagent | Forms | Powder |
| Product Brand | Thermo Fisher Scientific™, thermo Scientific | ||
| Product Grade | Molecular Biology | Formula | C₆H₅C(C₂H₅)=C(C₆H₅)C₆H₄OCH₂CH₂N(CH₃)₂ |
Thermo Scientific™ Tamoxifen (≥98%) is a selective estrogen receptor modulator (SERM) and antineoplastic compound used extensively in cancer biology, endocrinology, and molecular pharmacology.
It functions by competitively binding to estrogen receptors (ERs), thereby inhibiting estrogen-dependent gene transcription and DNA synthesis, leading to decreased tumor cell proliferation.
Beyond its classical anti-estrogenic effects, Tamoxifen also acts as a protein kinase C (PKC) inhibitor and induces apoptosis in cancer cells, making it a versatile research reagent for tumorigenesis, inflammation, and signal transduction studies.
Key Features
- High Purity: ≥97.5% (HPLC) confirmed by NMR.
- Mechanism of Action: Estrogen receptor antagonist and PKC inhibitor.
- Antineoplastic Properties: Inhibits estrogen-mediated DNA synthesis and IGF-1 production.
- Apoptosis Induction: Activates TGF-β and promotes programmed cell death in tumor cells.
- Broad Research Utility: Suitable for studies on cancer growth, inflammation, and microglial activation.
- Form: White to pale cream crystalline powder.
- Research Use Only (RUO): For laboratory use only; not for human or therapeutic applications.
Chemical Identifiers
| Property | Value |
|---|---|
| Chemical Name (IUPAC) | (Z)-2-[4-[(1,2-diphenylbut-1-en-1-yl)phenoxy]ethyl]dimethylamine |
| Synonyms | Tamoxifen, Citofen, Nolvadex, Tamoxifen citrate (salt form) |
| CAS Number | 10540-29-1 |
| Molecular Formula | C₂₆H₂₉NO |
| Molecular Weight | 371.52 g/mol |
| InChI Key | N/A |
Specifications
| Parameter | Specification |
|---|---|
| Purity (HPLC) | ≥97.5% |
| Form | Powder |
| Appearance | White to pale cream solid |
| NMR Verification | Conforms to structure |
| Solubility | Soluble in ethanol, DMSO, and methanol |
| Storage Conditions | Cool, dry, and well-ventilated place |
| Stability | Light and air sensitive |
| Intended Use | Research Use Only (RUO) |
Applications
- Oncology Research: Inhibition of estrogen receptor signaling in breast cancer models.
- Endocrinology: Analysis of estrogen-dependent gene expression.
- Neuroscience: Study of microglial activation and neuroinflammation.
- Cell Biology: Investigation of PKC inhibition and apoptosis induction.
- Molecular Pharmacology: Regulation of growth factor and cytokine pathways.
- In Vitro Studies: Suitable for mechanistic, receptor-binding, and signaling assays.
References
- Mikelman, S. et al., “Protein Kinase C Inhibitor Tamoxifen Inhibits Neurochemical and Behavioral Effects of Amphetamine.” FASEB J. (2015) 29(1), 930–1011.
- Chlebowski, R.T. “IBIS-I Tamoxifen Update: Maturity Brings Questions.” Lancet Oncol. (2015) 16(1), 7–9.
Safety & Handling
- Signal Word: Danger
-
Hazard Statements:
- H302 – Harmful if swallowed
- H350 – May cause cancer
- H360FD – May damage fertility or the unborn child
- H362 – May cause harm to breast-fed children
-
Precautionary Statements:
- P201 – Obtain special instructions before use
- P263 – Avoid contact during pregnancy and while nursing
- P280 – Wear protective gloves and eye protection
- P301 + P330 + P331 – If swallowed: Rinse mouth. Do NOT induce vomiting
- Classification: Acute Oral Toxicity Cat. 4 | Carcinogenicity Cat. 1A | Reproductive Toxicity Cat. 1A
The Thermo Scientific™ Tamoxifen (≥98%) is a research-grade estrogen receptor antagonist and antineoplastic reagent widely used to investigate hormone signaling, tumor growth, apoptosis, and PKC inhibition.
Its high purity and reproducible performance make it ideal for oncology, endocrinology, and neurobiology research, supporting detailed molecular studies under controlled conditions.
- Pack Size: 1g 5g 500 mg