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Specifications:
| Application | Cell culture, cell Signalling | ||
| Storage Temperature | -20°C | ||
| Product Type | Enzymes and Substrates | Forms | Solid |
| Product Brand | Thermo Fisher Scientific™, thermo Scientific | ||
| Product Grade | Analytical grade | Formula | C₁₄H₁₁N₃O₃S |
Thermo Scientific™ Nocodazole is a well-characterized microtubule-depolymerizing agent used widely in cell biology, cytogenetics, and cancer research. As a synthetic benzimidazole derivative, Nocodazole binds to β-tubulin and inhibits polymerization of microtubules, resulting in cell cycle arrest at G2/M phase—a mechanism that makes it a powerful tool in mitotic studies, synchronization protocols, and drug screening assays.
This compound is supplied as a high-purity powder (≥98% by HPLC), packaged in sealed glass bottles, and available in 10 mg and 50 mg quantities for research applications.
Key Features and Benefits
- High Purity: ≥98% by HPLC, ensuring reproducible performance in sensitive assays
- Microtubule Inhibitor: Disrupts tubulin polymerization, blocking cell cycle at metaphase
- Cell Synchronization Tool: Widely used for G2/M arrest in mammalian cell cultures
- Mechanism-Based Research Use: Supports studies in mitosis, cancer cell proliferation, and cytoskeletal dynamics
- Packaged for Precision: Supplied in 10 mg and 50 mg glass vials for small-scale and bulk research use
Chemical and Physical Properties
| Property | Description |
|---|---|
| Product Name | Nocodazole |
| CAS Number | 31430-18-9 |
| Molecular Formula | C₁₄H₁₁N₃O₃S |
| Molecular Weight | 301.32 g/mol |
| IUPAC Name | Methyl N-[6-(thiophene-2-carbonyl)-1H-benzimidazol-2-yl]carbamate |
| Appearance (Form) | Powder |
| Appearance (Color) | White to orange-brown |
| Purity | ≥98% (HPLC) |
| Infrared Spectrum | Conforms |
| SMILES | COC(=O)NC1=NC2=CC=C(C=C2N1)C(=O)C1=CC=CS1 |
| InChI Key | KYRVNWMVYQXFEU-UHFFFAOYSA-N |
| Use Classification | RUO – Research Use Only |
| Storage | Store according to label instructions in a cool, dry place |
Available Catalog Numbers and Packaging
| Catalog Number | Quantity | Packaging |
|---|---|---|
| 358240100 | 10 mg | Glass bottle |
| 358240500 | 50 mg | Glass bottle |
Applications
- Cell cycle synchronization (G2/M arrest)
- Mitotic spindle assembly studies
- Tubulin and microtubule inhibition assays
- Cancer cell proliferation and apoptosis research
- Antimitotic drug screening and resistance profiling
- Imaging and live-cell tracking of mitosis
Thermo Scientific™ Nocodazole, 98% is a trusted, high-performance tool for researchers investigating mitosis, microtubule dynamics, and cancer biology. With exceptional purity and consistent activity, it serves as an essential reagent in both fundamental and applied cell biology studies. Available in 10 mg and 50 mg formats, it meets the needs of both small-scale experiments and extended assay workflows in academic and pharmaceutical research environments.
- Pack Size: 10mg 50mg