Thermo Scientific™ Dextran sulphate sodium salt, M.W. ∼ 500,000

Polyanionic Polysaccharide for Colitis Research & Biomedical Applications

Thermo Fisher Scientific™ Dextran Sulfate Sodium (DSS) is a high-purity polyanionic derivative of dextran, produced by esterification of dextran with chlorosulfonic acid. DSS is widely used in biomedical and clinical research, particularly in inflammatory bowel disease (IBD) models and antiviral studies.

As a high molecular weight (≥500,000 Da) sodium salt, DSS is freely soluble in water and salt solutions, forming a stable, clear solution with controlled sulfation levels (17–20% sulfur content). This product is highly effective in inducing experimental colitis in animal models, making it an essential reagent for colitis research and IBD therapeutics evaluation.

Key Features & Benefits

✅ High Molecular Weight (≥500,000 Da) – Ensures reproducibility in biomedical applications

✅ Controlled Sulfation (17–20%) – Consistent biological activity with 1.9 sulfate groups per glucosyl residue

✅ Water-Soluble & Stable – Freely dissolves in aqueous solutions for easy preparation

✅ Proven Model for IBD Research – Induces chronic colitis in animal studies

✅ Versatile Biomedical Applications – Used in colitis studies, antiviral research, and macromolecular drug delivery

Applications

🔬 Inflammatory Bowel Disease (IBD) Research – Used to induce colitis in animal models (mice & rats)

🦠 Colitis-Associated Cancer Studies – Evaluates therapeutic interventions for IBD-related cancers

🧬 Antiviral Research – Studied as a potential antiviral agent

🛠️ Biopolymer & Drug Delivery Systems – Used in drug formulation & macromolecular studies

Product Specifications

Usage Guidelines

• Colitis Model Preparation:
  • DSS is administered via drinking water to induce chronic colitis in experimental animals
  • Concentration typically ranges from 2–5% (w/v) depending on the model
  • Symptoms include epithelial damage, inflammation, and immune activation
• Solution Preparation:
  • DSS is freely soluble in water and salt solutions
  • Dissolve in distilled water to prepare a homogeneous solution
  • Store prepared solutions at 2–8°C for short-term use or -20°C for long-term storage

Ordering Information

Regulatory & Safety Information

⚠️ For Research Use Only. Not intended for diagnostic, therapeutic, or human/animal use.

• Use in a controlled laboratory environment
• Handle with appropriate personal protective equipment (PPE)
• Refer to the Safety Data Sheet (SDS) for detailed handling and disposal guidelines

Why Choose Thermo Fisher Scientific™ Dextran Sulfate Sodium (DSS)?

🔹 Highly Purified & Well-Characterized – Ensures reproducibility in research applications

🔹 Validated in IBD & Colitis Models – Cited in numerous scientific studies

🔹 Stable & Easy to Use – Freely dissolves in water & salt solutions

🔹 Trusted by Researchers Worldwide – Backed by Thermo Fisher Scientific’s commitment to quality

For bulk orders, technical support, or additional information, contact LabMart Limited today.