0
Specifications:
| Application | Organic Synthesis | ||
| Storage Temperature | Ambient | ||
| Product Type | Laboratory Chemical | Forms | Liquid |
| Product Brand | Thermo Fisher Scientific™, thermo Scientific | ||
| Product Grade | Analytical grade | Formula | C₂H₃ClO |
Acetyl chloride is a highly reactive acid chloride widely used as a key acylating reagent in organic synthesis. With a minimum purity of 99% (GC), this Thermo Scientific grade is ideal for high-purity pharmaceutical, chemical, and academic research applications.
It appears as a clear, colorless liquid, and is known for its strong reactivity with water and alcohols, releasing hydrogen chloride upon hydrolysis. Acetyl chloride is a cornerstone reagent for introducing acetyl groups into alcohols, amines, phenols, and enols, making it essential in the synthesis of esters, amides, and ketones.
This reagent-grade compound is packaged in glass bottles for chemical stability and is available in multiple volume formats. Due to its volatility and corrosive nature, it must be handled under dry, inert atmosphere conditions.
Key Features
- Purity ≥99% (GC) with low water (≤0.02%) and chlorine (≤0.003%) impurities
- Highly reactive acylating agent for ester and amide synthesis
- Colorless, volatile liquid with strong acid chloride odor
- Ambient storage, but protect from moisture and heat
- Supplied in glass bottles for stability and contamination prevention
- Conforms to analytical reagent-grade specifications
Applications
- Acylation of alcohols and amines to form esters and amides
- Synthesis of intermediates for pharmaceuticals and agrochemicals
- Used in preparation of acetic anhydride, acetamides, and acetyl derivatives
- Reactant in fragrance, dye, and fine chemical production
- Employed in analytical chemistry and reagent derivatization
- Intermediate for polymer chemistry and functional materials
Chemical & Physical Properties
| Property | Value |
|---|---|
| Chemical Name | Acetyl Chloride |
| CAS Number | 75-36-5 |
| Molecular Formula | C₂H₃ClO |
| Molecular Weight | 78.5 g/mol |
| Boiling Point | 50–52 °C |
| Melting Point | –112 °C |
| Density | 1.104 g/cm³ |
| Flash Point | 4 °C (39 °F) |
| Refractive Index | 1.3310 – 1.3330 (20 °C, 589 nm) |
| Water Content | ≤0.02% |
| GC Purity | ≥99.4% |
| Chlorine Content | ≤0.003% (total Cl) |
| Appearance | Clear, colorless liquid |
| Storage Conditions | Ambient, away from moisture and direct sunlight |
Available Packaging
| Catalog Number | Pack Type | Pack Size | |
|---|---|---|---|
| 43262.AD | Glass bottle | 50 mL | |
| 43262.AK | Glass bottle | 250 mL | |
| 43262.K2 | Glass bottle | 1 L |
Thermo Scientific™ Acetyl Chloride, ≥99%, is a reliable, high-purity acid chloride reagent indispensable in organic synthesis, acylation reactions, and derivative manufacturing. Its consistent quality and reactivity make it a top choice for professionals in pharmaceutical R&D, chemical production, and academic laboratories requiring robust, moisture-sensitive reagents.
- Pack Size: 50 mL 250 mL 1 LIter