Sigma-Aldrich Chlorosulfonic acid 99%

Chlorosulfonic Acid (99%) is a highly reactive and strong acid synthesized by reacting sulfur trioxide (SO₃) with dry hydrogen chloride gas. It is a powerful electrophilic agent that serves as a sulfonating, dehydrating, oxidizing, and chlorinating agent, making it invaluable in various chemical synthesis and industrial applications. It is widely used for electrophilic olefin cyclization and other organic transformations. The acid is particularly noted for its effectiveness compared to other sulfonic acids.

Key Features & Benefits:

1. Versatile Reactivity:
   • Chlorosulfonic acid is a highly reactive electrophilic agent used for sulfonation, oxidation, chlorination, and dehydration, which makes it valuable in a variety of chemical synthesis processes.
2. Electrophilic Olefin Cyclization:
   • It has been reported to be a better electrophilic olefin cyclization agent in comparison to other sulfonic acids, enhancing the efficiency of specific reactions in synthetic chemistry.
3. Infrared Spectral Data:
   • The infrared spectra of Chlorosulfonic acid in its solid, liquid, and gaseous states have been extensively recorded, providing valuable insights into its chemical behavior in different phases.
4. High Purity:
   • This product is available with a purity of 99%, ensuring that it meets the high standards required for industrial synthesis and research applications.

Applications:

1. Synthesis of Ionic Liquids:
   • Chlorosulfonic acid is used to synthesize di-n-butyl ammonium chlorosulfonate, a secondary amine ionic liquid, which has various industrial and chemical applications.
2. Polymer Synthesis:
   • It can be used to prepare sulfonated polyethersulfone (SPES), a material with enhanced hydrophilic properties, making it useful for membrane applications in filtration and separation technologies.
3. Improving Anticoagulant Properties of Silk Fibroin:
   • The acid is employed in modifying silk fibroin, attaching a sulfate group to enhance its anticoagulant properties, which could be beneficial in biomedical applications.
4. Coumarin Synthesis:
   • Chlorosulfonic acid serves as a catalyst in the von Pechmann condensation reaction between phenol and β-ketoesters to synthesize substituted coumarins, which are important intermediates in organic chemistry and pharmaceuticals.
5. Biginelli Reaction:
   • It is used as an effective substitute to traditional acid catalysts in the Biginelli reaction to prepare 3,4-dihydropyrimidines, compounds with biological and pharmaceutical relevance.

Specifications:

Sigma-Aldrich Chlorosulfonic Acid (99%) is a highly effective and versatile reagent widely used in organic synthesis, polymer chemistry, and biochemical modifications. Its ability to act as a sulfonating agent and catalyst for electrophilic reactions makes it an essential tool in both industrial applications and scientific research. The high purity and reliable performance ensure that it meets the demands of high-precision applications in chemistry, pharmaceuticals, and biotechnology.