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Thermo Scientific™ Blasticidin, powder, 50mg
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Specifications:
| Application | Cell culture | ||
| Storage Temperature | -20°C | ||
| Product Type | Antibiotic | Forms | Lyophilized |
| Product Brand | Thermo Fisher Scientific™ | ||
| Product Grade | Molecular Biology | Formula | C₁₇H₂₆N₈O₅ · HCl |
Broad-Spectrum Antibiotic for Selection of Transformed Cells
Blasticidin S is a potent aminoacylnucleoside antibiotic that inhibits protein synthesis in both prokaryotic and eukaryotic cells. Supplied as a 50 mg powder, Thermo Scientific™ Blasticidin is widely used as a selection agent for mammalian and bacterial cells transfected with resistance genes such as bls, bsr, or BSD.
In addition to its use in molecular biology, Blasticidin S also exhibits fungicidal activity, making it valuable in agricultural research for preventing rice blast disease. Its primary mode of action involves inhibiting peptide bond formation and peptidyl-tRNA hydrolysis, which effectively halts translation.
Key Features and Benefits
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Selection of Transformed Cells
Ideal for selecting mammalian, bacterial, or yeast cells transfected with Blasticidin resistance genes (bls, bsr, BSD). -
Potent Mechanism of Action
Inhibits protein synthesis by interfering with peptidyl-tRNA hydrolysis and peptide bond formation on ribosomes. -
Broad-Spectrum Activity
Effective against a wide range of bacteria, eukaryotic cells, and fungi. -
High-Purity Powder
Supplied as a pure powder for custom concentration preparation—providing flexibility for various applications. -
Versatile Research Applications
Used in gene expression studies, protein synthesis research, and agricultural biotechnology.
Applications
- Selection of stable transfectants in mammalian cells (e.g., HEK293-T, HEK-D5)
- Bacterial or fungal resistance marker selection
- Functional gene expression and promoter activity studies
- Inhibition studies of protein translation
- Agricultural research and rice blast disease control
Chemical and Physical Properties
| Property | Details |
|---|---|
| Product Name | Blasticidin, Powder |
| Catalog Number | 461120 |
| CAS Number | 3513-03-9 |
| Molecular Formula | C₁₇H₂₆N₈O₅ · HCl |
| Molecular Weight | 458.90 g/mol |
| Form | Powder |
| Chemical Class | Aminoacylnucleoside |
| MDL Number | MFCD02091640 |
| PubChem Substance ID | 57647341 |
| UNSPSC Code | 51102829 |
| Packaging | Bottomless glass bottle with fused cone insert |
| Storage Conditions | Store as per label instructions |
| Product Type | Antibiotic |
| Unit Size | Each (50 mg) |
| Intended Use | For Research Use Only. Not for use in diagnostic procedures. |
Conclusion
Thermo Scientific™ Blasticidin (50 mg, Powder) is a trusted and effective antibiotic for selective pressure in molecular biology, as well as a valuable research tool for studying translation mechanisms. Its compatibility with BSD resistance genes makes it a top choice for transfected cell selection in modern genetic engineering workflows.