Thermo Scientific™ Trimethylamine 50% (w/w) 7.3 M in aqueous solution, pure

Trimethylamine (TMA) is a volatile, tertiary amine supplied here in 50% aqueous solution, providing a reliable and safe-to-handle format for use in chemical synthesis, analytical research, sensor development, and biomedical studies. As a precursor or analytical target of trimethylamine-N-oxide (TMAO), TMA plays a critical role in microbiota-host interaction studies, metabolomics, and disease biomarker research, especially in the context of cardiovascular disease and diabetes.

The 50% solution (7.3 M) offers high concentration and purity, ideal for academic, clinical, and material science applications.

Key Features

✅ High Purity and Concentration: 50% (w/w) aqueous solution (~7.3 M), ready for dilution or use in assays and synthesis

✅ Water-Soluble Format: Safe and convenient for laboratory use compared to gaseous TMA

✅ Versatile Reagent: Applicable in biological, chemical, and sensor development workflows

✅ Research-Grade Quality: Suitable for trace analysis, method development, or compound standardization

Scientific & Research Relevance

📘 Microbiota–Host Metabolism Studies

• TMA is a key microbial metabolite generated from dietary components such as choline, betaine, and L-carnitine.
• Stremmel et al. (2017) explored its transformation into trimethylamine-N-oxide (TMAO) in the liver—a critical pathway linked to atherosclerosis and cardiovascular disease.

📘 Diabetes and Metabolic Disorders

• Systemic TMAO levels (from TMA) are strongly linked to glucose dysregulation and insulin resistance.
• Dambrova et al. (2016) emphasized TMA as a therapeutic and diagnostic target in diabetes and metabolic syndrome.

📘 Sensor Development & Materials Science

• TMA is used as a model compound in gas sensor development.
• Studies such as Qiao et al. (2018) utilize MoS₂/SnO₂ heterojunctions and lanthanide MOFs (Min et al., 2022) for selective detection of TMA vapor.

📘 Nutritional and Environmental Studies

• TMA is central to studying diet-derived amines and their systemic effects, helping evaluate food safety, spoilage detection, and nutritional biomarkers.
• Referenced in Velasquez et al. (2016) as a critical analyte for public health research.

Use Cases

🔬 Analytical Chemistry & Sensor R&D

• TMA standard for gas sensor calibration, fluorescence detection, or ion-selective electrode development

🧬 Biomedical & Microbiome Research

• Use in modeling gut microbiota conversion pathways and liver TMAO biosynthesis

🌡 Environmental Monitoring

• TMA detection in waste streams and degradation products of organic material

🍽 Food Quality & Spoilage Detection

• Marker for fish and meat spoilage in freshness monitoring systems