Thermo Scientific™ Theophyllin monohydrate ≥99%

Theophylline monohydrate is a highly pure methylxanthine alkaloid, structurally similar to caffeine and theobromine. It functions as a non-selective phosphodiesterase (PDE) inhibitor, adenosine receptor antagonist, and bronchodilator. The compound is commonly used in research related to respiratory disease, inflammation, cardiovascular regulation, and reproductive toxicology.

Thermo Scientific™ offers this compound at ≥99% purity (titration), supplied as a white crystalline solid with consistent quality suitable for biochemical assays, pharmaceutical studies, and preclinical drug screening.

Available Pack Sizes

Specifications

Pharmacological and Biochemical Properties

• Mechanism of Action:
  • PDE inhibition → elevates intracellular cAMP and cGMP levels
  • Adenosine receptor antagonism (non-selective)
  • Smooth muscle relaxation and bronchodilation
• Biological Effects:
  • Bronchodilator used in asthma and COPD research
  • CNS stimulant at high concentrations
  • Demonstrates reproductive toxicity in high doses (via Sertoli cell damage)
  • Cardiac stimulant and diuretic

Research Applications

Theophylline monohydrate is widely used in studies involving:

• Respiratory Biology & Pulmonology:
  • Modeling asthma/COPD treatment pathways
  • Smooth muscle relaxation via cAMP signaling
• Reproductive Toxicology:
  • Effects on spermatogenesis, Sertoli cell function, and fertility
• Cell Signaling & Metabolism:
  • Phosphodiesterase inhibition and cAMP/PKA pathway activation
  • Used in research on metabolic rate regulation and adenosine receptor pharmacology
• Analytical Chemistry & HPLC:
  • Standard/reference compound in biofluid analysis

Preparation & Solubility Notes

• Solubility:
  • Soluble in 1 M NH₄OH (~50 mg/mL)
  • Moderately soluble in alcohol, dilute HCl/NaOH, and chloroform
  • Forms soluble complexes (e.g., aminophylline) to enhance aqueous solubility
• Formulation Considerations:
  • Often used to prepare double salts or 1:1 complexes to improve solubility and bioavailability

Thermo Scientific™ Theophylline Monohydrate (≥99%) is a research-grade methylxanthine ideal for studies in respiratory pharmacology, smooth muscle physiology, PDE inhibition, and toxicology. It serves as a reliable compound for applications involving cell signaling, adenosine receptor biology, drug solubility enhancement, and metabolic regulation. With high purity, well-characterized stability, and proven experimental versatility, it remains an indispensable compound for biomedical and pharmaceutical research.