Thermo Scientific™ Isoniazid ≥98%

Isoniazid, a key compound in the treatment of tuberculosis, is a hydrazide derivative of isonicotinic acid. This chemical is widely used as a first-line agent in the management of Mycobacterium tuberculosis infections. Its purity of ≥98% ensures reliability and efficacy for research and pharmaceutical applications.

Chemical and Physical Properties:

• Synonyms:
  • 4-Picolinic acid hydrazide
  • 4-Pyridinecarboxylic acid hydrazide
  • Isonicotinic hydrazide
  • Pyridine-4-carboxylic acid hydrazide
  • Isonicotinic acid hydrazide
• Chemical Formula: C₆H₇N₃O
• Molecular Weight: 137.14 g/mol
• CAS Number: 54-85-3
• MDL Number: MFCD00006426
• EINECS: 200-214-6

Physical Properties:

• Appearance: White to off-white crystalline powder
• Melting Point: 169–174°C
• Density: 1.42 g/cm³ (at 20°C)
• Flash Point: >250°C
• Purity: ≥98%

Applications:

1. Pharmaceutical Use:
   • Tuberculosis Treatment: Isoniazid is a first-line drug for treating tuberculosis, often used in combination with other antimicrobials to prevent the development of resistance.
   • Preventive Therapy: Utilized in prophylactic therapy to reduce the risk of latent tuberculosis reactivating in vulnerable populations.
2. Research Applications:
   • Microbiology: Used in studies to evaluate its effect on Mycobacterium tuberculosis and other mycobacteria.
   • Drug Resistance Studies: Investigating resistance mechanisms against isoniazid in tuberculosis-causing bacteria.
   • Biochemical Pathways: Evaluating its role in the inhibition of mycolic acid synthesis, a key component of bacterial cell walls.
3. Chemical Synthesis:
   • Used as a precursor or reagent in organic synthesis for creating hydrazine derivatives.
4. Analytical Use:
   • Employed as a standard or reference material in laboratories for testing and assay development.

Specifications:

• Beilstein Reference: 119374
• Merck Reference: 14,5186
• Storage Temperature: Ambient conditions

Packaging Information:

• Pack Sizes and Catalog Numbers:
  • 50 g: Catalog No. A10583.1
  • 100 g: Catalog No. A10583.22
  • 500 g: Catalog No. A10583.36
  • 1,000 g: Catalog No. A10583.0B
• Packaging Type: Glass bottle for solids

Storage and Handling:

• Storage:
  • Store at ambient temperature in a dry, well-ventilated area, away from direct sunlight and incompatible materials.
• Handling Precautions:
  • Use personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat.
  • Avoid inhalation, ingestion, or contact with skin and eyes.

Key Features:

• High purity (≥98%) for consistent and reliable results.
• Stable at ambient conditions for easy handling and storage.
• Suitable for a broad range of research, pharmaceutical, and analytical applications.
• Supplied in secure glass bottles to maintain product integrity.

Thermo Scientific Isoniazid is an essential compound with critical applications in microbiology, pharmaceutical research, and organic synthesis. Its high purity and reliable properties make it an indispensable tool for researchers and manufacturers working on tuberculosis treatment and other related studies.