Thermo Scientific™ Diphenylphosphoryl azide ≥97%

Diphenylphosphoryl azide (DPPA) is a versatile azide transfer reagent widely used in organic synthesis, particularly in Curtius rearrangements, amide/peptide bond formation, and heterocycle synthesis. Supplied by Thermo Fisher Scientific at ≥97% purity, DPPA is suitable for academic, pharmaceutical, and industrial research laboratories engaged in developing novel molecules, drug candidates, and functionalized intermediates.

Due to its high reactivity and broad utility in azidation chemistry, DPPA serves as a critical intermediate in phosphorylation, urea synthesis, and azide-related coupling reactions.

Key Features

• ≥97% assay purity verified by standard analytical methods
• Supplied as a colorless to pale yellow liquid or crystalline solid
• Reactive azide donor for acyl azide and isocyanate intermediate synthesis
• Excellent reagent for Curtius and Staudinger-type reactions
• High reactivity under mild conditions in the presence of catalysts
• Provided in securely sealed glass bottles with full documentation (SDS, CoA)

Chemical & Physical Properties

Packaging Options

Applications

• Azide transfer reactions in heterocycle and alkyl azide synthesis
• Curtius rearrangements to synthesize isocyanates and amines
• Peptide coupling reagent in carbodiimide-free conditions
• Preparation of urethanes, ureas, and other nitrogen-containing compounds
• Pharmaceutical R&D: Synthesis of bioactive molecules and drug intermediates
• Functional group interconversion via nucleophilic substitution reactions

Safety & Handling

• Classified as toxic and irritant—use only in well-ventilated fume hoods
• Handle with gloves, goggles, and protective lab wear
• Avoid heat, friction, or shock during transfer and usage
• Store in tightly sealed containers under ambient conditions, away from acids and oxidizers
• Refer to SDS (msds_ALFAA12124) for detailed handling, hazard, and disposal instructions

Diphenylphosphoryl Azide ≥97% – Thermo Fisher Scientific is a high-purity, multifunctional azide reagent tailored for synthetic organic chemists seeking precision, efficiency, and reproducibility. With validated performance in azidation, Curtius rearrangement, and amide synthesis, DPPA is a trusted building block for complex molecule development, drug discovery, and academic chemical research.