Thermo Scientific™ Dexamethasone ≥98%

Dexamethasone is a synthetic glucocorticoid steroid with exceptionally high anti-inflammatory and immunosuppressive potency, but with minimal mineralocorticoid activity. It is frequently used in biomedical and translational research to modulate immune responses, induce cell differentiation, and study hormone-mediated gene regulation. Its potent and selective action on glucocorticoid receptors (GR) makes it a cornerstone reagent in cell biology, oncology, immunology, and regenerative medicine.

Thermo Scientific provides ≥98% HPLC-pure dexamethasone, ensuring consistency and reliability for demanding experimental applications.

Available Pack Sizes

Specifications

Biological & Pharmacological Actions

• Mechanism of Action:
  Dexamethasone binds to cytosolic glucocorticoid receptors (GR), leading to nuclear translocation and regulation of gene transcription. It inhibits the expression of pro-inflammatory cytokines and enzymes, and promotes anti-inflammatory gene expression.
• Physiological Effects:
  • Reduces inflammation by inhibiting leukocyte infiltration
  • Suppresses immune responses through lymphocyte activity reduction
  • Inhibits the synthesis of nitric oxide synthase (NOS)
  • Modulates T-cell proliferation, survival, and differentiation
• Compared to Other Glucocorticoids:
  Dexamethasone is significantly more potent than cortisol or hydrocortisone, with a longer half-life and more targeted action in anti-inflammatory signaling pathways.

Applications in Research

Dexamethasone is widely used across a range of experimental systems:

• Stem Cell Research:
  • Induces osteogenic and adipogenic differentiation in mesenchymal stem cells (MSCs)
  • Used in chondrogenic media formulations
• Pulmonary and Airway Inflammation Models:
  • Used to stimulate normal human bronchial epithelial (NHBE) and airway smooth muscle (ASM) cells
  • Mimics glucocorticoid therapy in models of asthma, COPD, and cystic fibrosis
• Cancer and Immunology Research:
  • Suppresses immune signaling in tumor microenvironments
  • Part of standard combination regimens in multiple myeloma models
  • Investigated for its neuroprotective and anti-edematous effects in CNS injury models
• Endocrinology & Metabolism:
  • Modulates glucose metabolism and lipid catabolism
  • Mimics stress hormone action in HPA axis studies

Handling and Storage

• Storage Temperature: Ambient (20–25 °C)
• Light Sensitivity: Protect from light to prevent degradation
• Reconstitution:
  • Dissolve in ethanol, methanol, or DMSO
  • Aliquot and store solutions at −20 °C for long-term use
  • Avoid repeated freeze-thaw cycles

Thermo Scientific™ Dexamethasone (≥98%) is a high-purity, research-grade synthetic corticosteroid ideal for applications in inflammation biology, endocrine research, stem cell differentiation, oncology, and autoimmune modeling. Its superior glucocorticoid receptor selectivity and long biological half-life make it a vital reference compound for cell signaling modulation, hormone response studies, and drug screening platforms.