Thermo Scientific™ 6-Hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic cid 97% (Trolox)

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Formula: C₁₄H₁₈O₄
CAS Number: 53188-07-1

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Specifications:
Application Colorimetric Assay, ELISA-Based Assays
Storage Temperature Ambient
Product Type Laboratory Chemical Forms Powder
Product Brand Thermo Fisher Scientific™, thermo Scientific
Product Grade Analytical grade Formula C₁₄H₁₈O₄

6-Hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid, commonly referred to as Trolox, is a water-soluble analogue of vitamin E (α-tocopherol). It is widely used as a standard antioxidant in biochemical and pharmaceutical research for the quantitative analysis of antioxidant capacity, including ABTS and ORAC assays.

With a high purity level of ≥97% and well-characterized physicochemical properties, Trolox is the preferred reference compound in studies involving reactive oxygen species (ROS), free radical scavenging, and lipid peroxidation inhibition.

Key Features

  • ≥97% purity by titration with NaOH
  • Powerful antioxidant standard in biochemical assays
  • Water-soluble analog of α-tocopherol (vitamin E)
  • Consistent melting range (187–194 °C)
  • Crystalline powder, easy to handle and dissolve
  • GHS07 classification – handle with standard laboratory PPE
  • Stable at ambient conditions

Applications

  • Reference standard for antioxidant capacity assays (e.g., ORAC, ABTS, DPPH)
  • Research on oxidative stress and cellular protection mechanisms
  • Assessment of free radical scavenging activity
  • Nutraceutical and cosmetic ingredient evaluation
  • Used in biomedical, food science, and pharmaceutical R&D
  • Alternative to α-tocopherol in aqueous systems

Chemical & Physical Properties

PropertySpecification
Chemical Name6-Hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid
Common NameTrolox
CAS Number53188-07-1
Molecular FormulaC₁₄H₁₈O₄
Molecular Weight250.29 g/mol
MDL NumberMFCD00006846
Melting Point187–194 °C
AppearanceWhite to light beige crystalline powder
Titration Purity≥96.0% (NaOH)
Storage ConditionsAmbient
Hazard ClassificationGHS07 – Irritant

Available Packaging

Catalog Number
Pack TypePack Size
218940010
Glass bottle1 g
218940050
Glass bottle5 g
218940250
Glass bottle25 g


Thermo Scientific™ Trolox, 97% is a gold-standard antioxidant reference reagent widely used in redox biology, food chemistry, and nutraceutical science. Its excellent solubility and stability, combined with high purity, make it essential for standardized antioxidant evaluations and comparative studies.

  • Pack Size:   1g 5g 25g
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