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Specifications:
| Application | Analysis | ||
| Storage Temperature | 2-8°C | ||
| Product Type | Laboratory Chemical | Forms | Powder |
| Product Brand | Thermo Fisher Scientific™, thermo Scientific | ||
| Product Grade | Analytical grade | Formula | C₁₀H₁₇N |
Amantadine Precursor and Enantioselective Reaction Catalyst
1-Adamantanamine (also known as amantadine or adamantan-1-amine) is a rigid, tricyclic primary amine commonly used in pharmaceutical synthesis, catalysis, and supramolecular chemistry. This compound is the precursor to amantadine hydrochloride, a well-known antiviral and antiparkinsonian drug. It also serves as a chiral organocatalyst in enantioselective Strecker-type reactions involving phosphinoyl imines.
This high-purity (≥98%) crystalline amine is ideal for research in drug development, catalytic reaction design, and functional material modification.
Key Features & Benefits
- High assay quality (≥97.5%) confirmed by non-aqueous titration and FTIR
- Multifunctional amine for both synthetic and pharmaceutical chemistry
- Catalyst in asymmetric Strecker reactions and other enantioselective transformations
- Building block for adamantane derivatives, especially antiviral and CNS drugs
- Available in multiple sizes for R&D scale applications
Applications
- Intermediate for amantadine hydrochloride synthesis
- Catalyst in asymmetric Strecker reactions
- Antiviral and antiparkinsonian drug research
- Modifier in zeolite and membrane functionalization
- Guest molecule in supramolecular host–guest studies (e.g., cucurbituril complexes)
- Structural scaffold in rigid polycyclic compound design
For Research Use Only (RUO). Not for use in diagnostic or therapeutic procedures.
Chemical & Physical Properties
| Attribute | Value |
|---|---|
| CAS Number | 768-94-5 |
| Synonyms | Amantadine, aminoadamantane, virosol |
| Molecular Formula | C₁₀H₁₇N |
| Molecular Weight | 151.25 g/mol |
| Appearance | White crystals or crystalline powder |
| Purity (Titration) | ≥97.5% – ≤102.5% |
| Solubility | Soluble in organic solvents; insoluble in water |
| Form | Solid (powder/crystals) |
| Storage Conditions | Store in a cool, dry, ventilated place |
| Handling | Use in a fume hood; avoid ignition sources |
| Incompatibilities | Strong oxidizing agents |
Ordering Information
| Product Description | Catalog Number | Quantity |
|---|---|---|
| 1-Adamantanamine, 98% | H30076.06 | 5 g |
| 1-Adamantanamine, 98% | H30076.14 | 25 g |
| 1-Adamantanamine, 98% | H30076.22 | 100 g |
References
- Yang et al. Chem. Commun. (2013): Host–guest interactions with cucurbit[7]uril
- Bose et al. RSC Adv. (2015): Zeolite membrane modification using 1-adamantanamine
Thermo Scientific™ 1-Adamantanamine, 98% is a versatile and robust molecule widely used in pharmaceutical, catalytic, and materials science research. As both a synthetic precursor and chiral auxiliary, it provides a rigid and stable scaffold ideal for designing bioactive molecules, catalysts, and functionalized surfaces. It is an essential reagent for academic and industrial R&D programs focused on CNS therapies, supramolecular chemistry, and asymmetric synthesis.
- Pack Size: 100g 5g 25g