MP Biologicals Dextran sulphate sodium (DSS) salt, Colitis Grade

High-Purity DSS for Inflammatory Bowel Disease (IBD) Research & Antiviral Applications

Product Overview

MP Biomedicals Dextran Sulfate Sodium (DSS) Salt is a polyanionic derivative of dextran produced through esterification with chlorosulfonic acid, making it a versatile reagent in biomedical and clinical research. DSS is widely used for inducing colitis (Inflammatory Bowel Disease, IBD) in animal models, aiding in the study of colitis-associated cancer and therapeutic interventions. Additionally, DSS has shown potential antiviral activity in various studies.

This colitis-grade DSS is a white to off-white powder, freely soluble in water and salt solutions, forming a stable, clear solution. It contains approximately 17-20% sulfur, which corresponds to an average of 1.9 sulfate groups per glucosyl residue in the dextran molecule.

Key Features & Benefits

✅ High-Quality Colitis-Grade DSS – Trusted reagent for colitis research in animal models

✅ Controlled Molecular Weight (36,000 - 50,000 Da) – Ensures reproducibility in experiments

✅ Reliable In Vivo Model for IBD Research – Used in DSS-induced colitis models

✅ Water-Soluble Polysaccharide – Forms a stable, clear solution in aqueous environments

✅ High Sulfation Degree (~18-20% Sulfur Content) – Ensures consistent biological effects

✅ Dual Application – Used in colitis research and as a potential antiviral agent

✅ Stringent Quality Testing – Passes identity, moisture, sulfur, and glucose purity tests

Applications

🔬 Inflammatory Bowel Disease (IBD) Research – Used in DSS-induced colitis animal models

🦠 Colitis-Associated Cancer Studies – Evaluates disease progression and therapeutic interventions

🧬 Antiviral Research – Investigated for potential inhibition of viral replication

🛠️ Biomedical & Clinical Research – Examines intestinal inflammation and immune response

Dextran Sulfate Sodium (DSS) Induced Colitis Model

• IBD & Chronic Colitis: DSS is administered orally in drinking water of mice or rats to induce colonic inflammation, mimicking human ulcerative colitis.
• Spontaneous Model: DSS directly affects the epithelial barrier, leading to chronic inflammation without genetic modifications.
• Therapeutic Assessment: Used to test potential treatments for colitis, IBD, and colon cancer.

Product Specifications

Usage Guidelines

Preparation of DSS Solution for Colitis Model:

1. Dissolve DSS Powder in autoclaved, distilled water to the required concentration (e.g., 1-5%).
2. Sterile-Filter the Solution (if needed) for in vivo use.
3. Administer DSS in Drinking Water to induce colitis in animal models.
4. Monitor Animal Health and adjust concentration as required for study duration.

Safety Considerations:

• Use in a well-ventilated area and handle with appropriate personal protective equipment (PPE).
• Store at ambient temperature in a dry, tightly sealed container.
• Refer to the Safety Data Sheet (SDS) for handling and disposal instructions.

Ordering Information

Shelf Life: Long-term stability under ambient storage conditions.

Regulatory & Safety Information

⚠️ For Research Use Only. Not intended for diagnostic, therapeutic, or human/animal use.

• DSS should be handled according to standard laboratory safety protocols.
• Ensure proper waste disposal in compliance with local regulations.

Why Choose MP Biomedicals Dextran Sulfate Sodium (DSS) Salt?

🔹 Gold-Standard DSS for Colitis Research – Cited in thousands of scientific publications

🔹 Proven Performance in IBD Models – Reliable, reproducible inflammation induction

🔹 High Purity & Controlled Sulfation – Ensures biological consistency in research

🔹 Versatile Applications – Supports colitis, cancer, and antiviral research

🔹 Multiple Packaging Options – Available in various sizes for different research needs

For bulk orders, technical support, or additional information, contact LabMart Limited today.